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Hartford Healthcare | Cancer Clinical Research Office

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Active trials

9 of 36 total trials
Locations recently updated

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermed...

Enrolling
Myelofibrosis
Drug: Imetelstat
Drug: Best Available Therapy (BAT)

The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure...

Enrolling
Heart Failure with Moderately Reduced Ejection Fraction
Diastolic Heart Failure
Device: OPTIMIZER™ Smart Mini System
Device: Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System

The goal of this clinical trial is to demonstrate that the OPTIMIZER® Integra CCM-D System (the "CCM-D System") can safely and effective convert indu...

Enrolling
Heart Failure with Reduced Ejection Fraction
CCM Therapy
Device: OPTIMIZER® Integra CCM-D System (Treatment Arm)

The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of n...

Enrolling
Persistent Atrial Fibrillation
Longstanding Persistent Atrial Fibrillation
Procedure: Surgical Ablation
Device: Cardioblate and Cryoflex hand held devices

Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic...

Enrolling
Intramural Hematoma
Penetrating Aortic Ulcer
Device: NEXUS Aortic Stent Graft System

A Phase 2 multi-center open-label basket trial of nab-sirolimus for adult and adolescent patients with malignant solid tumors harboring pathogenic in...

Active, not recruiting
Solid Tumor
Malignant Neoplasm
Drug: nab-sirolimus

The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine...

Enrolling
Solid Tumor
Rectal Adenocarcinoma
Drug: capecitabine or 5-FU
Drug: TSR-042 or Dostarlimab

Tamibarotene is being studied as a treatment for participants with a type of leukemia called acute myeloid leukemia, or AML for short. Tamibarotene i...

Active, not recruiting
Acute Myeloid Leukemia
Drug: Azacitidine
Drug: Venetoclax

The purpose of this study is to find out whether treatment with the study drug durvalumab combined with a type of radiation therapy called stereotact...

Enrolling
Non-small Cell Lung Cancer Stage II
PD-L1 Gene Mutation
Radiation: Stereotactic Body Radiation Therapy
Drug: Durvalumab

Trial sponsors

Memorial Sloan Kettering Cancer Center (MSK) logo
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Regeneron Pharmaceuticals logo
A
Bristol-Myers Squibb (BMS) logo
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Hartford Hospital logo
Mass General Brigham logo
McMaster University logo

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