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HCA Healthcare UK | Sarah Cannon Research Institute

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Active trials

23 of 60 total trials

A Phase 1 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia

The goal of this clinical trial is to learn if the drug STP938 works to treat adults with high risk essential thrombocythaemia (ET) who are resistant...

Enrolling
Essential Thrombocythaemia
Drug: STP938
Locations recently updated

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carbop...

Enrolling
KRAS G12C Lung Cancer
Non-Small Cell Lung Cancer
Drug: Cisplatin
Drug: Pemetrexed

This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combina...

Enrolling
Metastatic Colorectal Cancer
Drug: Inavolisib
Diagnostic Test: FoundationOne®Liquid CDx

This is a Phase 1/2 open-label, multi-center, multi-national study with an initial dose escalation part to determine the recommended Phase II dose (R...

Enrolling
Esophageal Cancer
Gastric Cancer
Combination Product: MCLA-158 + FOLFOX
Combination Product: MCLA-158 + FOLFIRI

A phase 1/2 dose escalation / dose expansion study of Enzomenib (DSP-5336) in adult patients with acute leukemia.

Enrolling
Leukemia, Lymphocytic, Acute
Leukemia, Myeloid, Acute
Drug: azoles
Drug: Azacitidine (AZA)

The main aim of this study is to find out how well elritercept works in lowering the need for RBC transfusions. Other aims are to learn how well elri...

Enrolling
Myelodysplastic Syndromes
Drug: Placebo
Drug: Elritercept

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer...

Active, not recruiting
Urothelial Cancer
Drug: Erdafitinib
Drug: Docetaxel

The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants wit...

Enrolling
Recurrent Head and Neck Squamous Cell Carcinoma
Metastatic Head-and-neck Squamous-cell Carcinoma
Other: Placebo
Biological: Cetuximab

This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in pa...

Enrolling
Triple Negative Breast Cancer (TNBC)
Metastatic Castration-resistant Prostate Cancer (mCRPC)
Drug: Paclitaxel
Drug: NX-1607

This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also s...

Enrolling
Ovarian Neoplasms
Melanoma
Drug: pembrolizumab
Drug: PF-08046054

This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it...

Enrolling
Uterine Cervical Neoplasms
Ovarian Neoplasms
Drug: carboplatin
Drug: pembrolizumab

This is a Phase I/II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immun...

Active, not recruiting
NSCLC Harboring NRG1 Fusion
Solid Tumours Harboring NRG1 Fusion
Drug: zenocutuzumab (MCLA-128)

The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with locally advanced or metastatic soli...

Enrolling
HGG
Solid Tumors
Drug: Plixorafenib

This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, im...

Enrolling
Locally Advanced Solid Tumors
Metastatic Solid Tumors
Drug: RO7566802
Drug: Atezolizumab

This is a first-in-human, Phase I, open-label, multicenter, dose-escalation and dose expansion study to evaluate the safety, tolerability, pharmacoki...

Enrolling
Advanced Solid Tumors
Drug: VVD-133214
Drug: Pembrolizumab

This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-ce...

Enrolling
Metastatic Non Small Cell Lung Cancer
Biological: LN-145

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor...

Active, not recruiting
Breast Cancer
Melanoma
Drug: Entrectinib

This two-part study will include a dose escalation part to determine the recommended dose for expansion of DS8201a and pembrolizumab and a dose expan...

Active, not recruiting
Breast Cancer
Non-small Cell Lung Carcinoma
Drug: Trastuzumab deruxtecan (DS-8201a)
Drug: Pembrolizumab

This is a study to investigate the potential clinical benefit of G1T38 as an oral therapy in combination with fulvestrant in patients with hormone re...

Active, not recruiting
Breast Cancer
Breast Neoplasm
Drug: Fulvestrant
Drug: G1T38

This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-pos...

Enrolling
Advanced Melanoma
Drug: Nivolumab + Relatlimab
Drug: Nivolumab

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