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Active trials

8 of 90 total trials
New

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in...

Begins enrollment in 2 months
Metabolic Dysfunction-Associated Steatotic Liver Disease
Drug: Tirzepatide
Drug: Placebo

The goal of this clinical trial is to assess the safety, reactogenicity and immunogenicity of an mRNA-based vaccine, JCXH-108, the prevention of Resp...

Active, not recruiting
Respiratory Syncytial Virus (RSV)
Infectious Disease
Other: Placebo
Biological: JCXH-108

This study is researching an investigational drug, ALN-HSD called "study drug". This study is focused on participants who are known to have metabolic...

Enrolling
Metabolic Dysfunction-associated Steatohepatitis (MASH)
Drug: Placebo
Drug: ALN-HSD

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Active, not recruiting
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

This study is open to adults who are at least 18 years old and have* presumed or confirmed NASH together with overweight or obesity and* a body mass...

Active, not recruiting
Non-Alcoholic SteatoHepatitis (NASH)
Obesity
Drug: Survodutide
Drug: Placebo

The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripher...

Enrolling
Diabetic Peripheral Neuropathic Pain
Drug: Placebo (matched to pregabalin)
Drug: Placebo (matched to VX-993)

This is an estimation-focused Phase 2 study designed to explore and quantify treatment-related changes across multiple clinical outcomes in patients...

Active, not recruiting
Alzheimer Disease
Drug: MAR

The purpose of this study is to evaluate the effectiveness of CD388 in preventing symptomatic laboratory-confirmed influenza infections, as compared...

Active, not recruiting
Influenza
Combination Product: CD388 Injection
Combination Product: Placebo

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