Hoag Memorial Hospital Presbyterian | Newport Beach, CA

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One Hoag Drive, Newport Beach, California, United States of America
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51 of 162
Status: Active
Trial type: Interventional
Funder type: Industry

177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

A Multi-Center, Open-Label, Randomized Phase 3 Trial Comparing the Safety and Efficacy of 177Lu-PSMA-I&T versus Hormone Therapy in Patients with Meta...

Active, not recruiting
Metastasis From Malignant Tumor of Prostate
Drug: Abiraterone with Prednisone or Enzalutamide
Drug: 177Lu-PSMA-I&T

The goal of this clinical trial is to test CPO301, a type of drug called an antibody drug conjugate in adult patients with advanced or metastatic sol...

Cancer, Lung
Drug: CPO301

A randomized controlled trial (RCT) to assess the safety and efficacy of use of Control-IQ technology in adults with type 2 diabetes using basal-bolu...

Type 2 Diabetes Treated With Insulin
Device: t:slim X2 insulin pump with Control-IQ technology 1.5 and Dexcom G6 CGM
Device: Standard Therapy plus continuous glucose monitoring (CGM)

This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combina...

Metastatic Colorectal Cancer
Drug: Inavolisib
Drug: Cetuximab

The purpose of this study is to assess the safety, tolerability, and recommended dose(s) of BMS-986340 as monotherapy and in combination with nivolum...

Ovarian Neoplasms
Drug: BMS-986340
Drug: BMS-936558-01

A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Pati...

Active, not recruiting
Gastric Cancer
GastroEsophageal Cancer
Drug: Capecitabine 1000mg/ m2 BID
Drug: DKN-01 600mg

The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease.Additional part...

Active, not recruiting
Alzheimer Disease
Drug: Donanemab
Drug: Placebo

This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity...

Any Solid Tumor
Colon Cancer
Drug: LOXO-292

The purpose of this study is to assess the safety, tolerability, and efficacy of BMS-986158 alone and in combination with either Ruxolitinib or Fedra...

Active, not recruiting
Drug: Ruxolitinib
Drug: BMS-986158

The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called varian...

SARS-CoV-2 Virus
Biological: Variant-adapted BNT162b2 (Omicron XBB.1.5) 3 microgram dose
Biological: Variant-adapted BNT162b2 (Omicron XBB.1.5) 10 microgram dose

The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment a...

Active, not recruiting
Alzheimer's Disease
Drug: Aducanumab
Drug: Placebo

This is a multicenter, randomized study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as mainten...

Ulcerative Colitis
Drug: Placebo
Drug: ABX464

This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinica...

Ulcerative Colitis
Drug: Placebo
Drug: ABX464

The primary purpose of this study is to determine whether treatment with lecanemab is superior to placebo on change from baseline of the Preclinical...

Preclinical Alzheimer's Disease
Early Preclinical Alzheimer's Disease
Drug: Lecanemab
Drug: Placebo

The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects with sy...

Aortic Stenosis, Severe

This is a research study to evaluate the safety of an investigational autologous cell product obtained from participant's own adipose tissue as a pos...

Alzheimer Disease
Biological: RB-ADSC

This is a double-blind study in which approximately 99 study patients will be randomized in a 2:1 ratio to receive either AVOVA-1 or MC. Patients eli...

Active, not recruiting
Stage III Ovarian Carcinoma
Primary Peritoneal Carcinoma
Biological: MC
Biological: AVOVA-1

This is a single-arm, open-label phase II clinical trial in which approximately 55 patients with newly diagnosed glioblastoma (GBM) will be enrolled...

Active, not recruiting
Newly Diagnosed Glioblastoma
Biological: AV-GBM-1

The objective of the study is to evaluate the safety and effectiveness of the HARPOON™ System in the treatment of patients with severe degenerative m...

Active, not recruiting
Mitral Regurgitation
Device: HARPOON™ Beating Heart Mitral Valve Repair System

This study will evaluate the feasibility of optimizing the safety and tolerability of serabelisib (an investigational PI3K inhibitor) when combined w...

Active, not recruiting
PTEN Loss of Function Mutation
PIK3CA Mutation
Drug: Nab paclitaxel
Drug: Serabelisib

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