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Active trials

30 of 92 total trials

A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

This is a multi-center clinical study enrolling up to 86 participants. The primary objectives are to determine the objective response rate (ORR) esta...

Enrolling
Recurrent Squamous Cell Carcinoma
Device: DaRT seeds

The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.

Enrolling
Crohn's Disease
Drug: Mirikizumab

This is a prospective, multicenter, single arm study designed to evaluate the safety and efficacy of the Temporary Bare Spur Stent System (Spur Stent...

Active, not recruiting
Critical Limb Ischemia
Peripheral Arterial Disease
Device: Bare Temporary Spur Stent System

TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for athero...

Enrolling
Diabetes Mellitus, Type 2
Metabolic Syndrome
Device: The Cleerly CAD Staging System
Locations recently updated

This study aims to examine the efficacy and safety of obexelimab in participants with relapsing multiple sclerosis

Enrolling
Relapsing Multiple Sclerosis
Drug: Placebo
Drug: Obexelimab

The purpose of this study is to evaluate the incidence rate and severity of prespecified mirvetuximab soravtansine (MIRV)-related ocular treatment-em...

Enrolling
Recurrent Ovarian Cancer
Folate Receptor-Alpha Positive
Drug: Lubricating Eye Drops
Drug: Prednisolone acetate ophthalmic suspension 1% eye drops

The primary purpose of this clinical trial is to compare the effects of study medicine (Ponsegromab/PF-06946860) with a placebo (an injection that lo...

Enrolling
Heart Failure
Drug: Optional Cohort C: Ponsegromab low dose
Other: Optional Cohort C: Matched placebo

This is a phase II single arm trial to determine the percentage of patients without evidence of disease progression on abemaciclib and letrozole in a...

Active, not recruiting
Endometrial Cancer
Drug: Letrozole
Drug: Abemaciclib

POWER PAD 2 is a prospective, single-arm, multicenter, non-randomized clinical study designed to demonstrate the safety and effectiveness of the Ampl...

Enrolling
Peripheral Arterial Disease (PAD)
Device: Pulse Intravascular Lithotripsy (Pulse IVL)

The research study is being done to see if ziltivekimab can be used to treat people who were admitted to hospital because of a heart attack. Ziltivek...

Enrolling
Acute Myocardial Infarction (AMI)
Cardiovascular Risk
Drug: Ziltivekimab
Drug: Placebo

Evaluate the safety and efficacy of the Aventus Thrombectomy System for aspiration thrombectomy in subjects with acute pulmonary embolism.

Enrolling
Pulmonary Embolism
Embolism
Device: Thrombectomy

This is a phase IIa randomized trial designed to evaluate bacteriophage therapy in patients with diabetic foot osteomyelitis.

Enrolling
Osteomyelitis
Diabetic Foot Osteomyelitis
Biological: Phage Therapy
Other: Placebo

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maint...

Enrolling
Venous Thromboembolism
Deep Venous Thrombosis
Device: ClotTriever System
Drug: Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.

The PERFORMANCE III study is a prospective, multicenter single-arm, open label study to evaluate the safety and effectiveness of the Neuroguard IEP®...

Enrolling
Carotid Stenosis
Carotid Artery Diseases
Device: Neuroguard IEP Direct System

The Esprit BTK PAS is a prospective, single-arm, multi-center observational study to assess the continued safety and effectiveness of the Esprit™ BTK...

Enrolling
Chronic Limb-Threatening Ischemia
Device: Esprit BTK System
Locations recently updated

Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin A...

Enrolling
Stage IV Primary Peritoneal Cancer
Stage III Ovarian Cancer
Other: No treatment
Drug: Cisplatin

This is a study of pembrolizumab (MK-3475, KEYTRUDA®) in combination with lenvatinib (E7080) versus treatment of physician's choice (doxorubicin or p...

Active, not recruiting
Endometrial Neoplasms
Drug: Doxorubicin
Drug: Paclitaxel

The objective of this prospective, single-blinded, randomized controlled clinical investigation is to evaluate the safety and efficacy of the everoli...

Active, not recruiting
Critical Limb Ischemia (CLI)
Device: Percutaneous Transluminal Angioplasty (PTA) Device
Device: Esprit BTK Device

IMGN853-0420 is a multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continua...

Active, not recruiting
Primary Peritoneal Cancer
High Grade Ovarian Cancer
Drug: Mirvetuximab soravtansine
Drug: Carboplatin

GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine as maintenance therapy...

Enrolling
Peritoneal Cancer
Fallopian Tube Cancer
Drug: Bevacizumab
Drug: Mirvetuximab soravtansine plus Bevacizumab

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