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Hospital Regional Universitario de Malaga | Hospital Civil - Rheumatology Department

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Active trials

33 of 71 total trials

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC) (DeLLphi-301)

The main aim of this study is to:* evaluate safety and efficacy (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST 1.1\] by inves...

Active, not recruiting
Relapsed/Refractory Small Cell Lung Cancer
Drug: Tarlatamab

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche...

Active, not recruiting
Multiple Sclerosis
Drug: Ocrelizumab

The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemoth...

Enrolling
Non-Small Cell Lung Cancer (NSCLC)
Drug: Sotorasib
Drug: Pembrolizumab

A study designed to evaluate the safety of crovalimab with eculizumab in participants with PNH currently treated with complement inhibitors. This stu...

Active, not recruiting
Paroxysmal Nocturnal Hemoglobinuria
Drug: Eculizumab
Drug: Crovalimab

The main aim of this study is to check if there are side effects from BAX 888 and to determine the dose of BAX 888 for treating severe hemophilia A i...

Active, not recruiting
Hemophilia A
Drug: BAX 888

Brigatinib is a medicine that binds to the surface of tumor cells in some cancers and delivers a dose of chemotherapy directly to the tumor. In this...

Active, not recruiting
ALK+ Advanced NSCLC
Drug: Brigatinib
Drug: Alectinib

The Phase 1b part of this study is conducted to assess the safety and tolerability of E7386 in combination with pembrolizumab in participants with pr...

Active, not recruiting
Melanoma
Carcinoma, Hepatocellular
Drug: E7386
Drug: Lenvatinib

This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) ate...

Enrolling
Extensive Stage-small Cell Lung Cancer
Drug: Ifinatamab deruxtecan
Drug: Carboplatin

This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lun...

Enrolling
Small Cell Lung Cancer
Drug: Topotecan
Drug: Amrubicin

The main goal of this trial is to evaluate the safety and tolerability of mRNA-3745 via intravenous (IV) administration in adult and pediatric partic...

Enrolling
Glycogen Storage Disease
Drug: mRNA-3745

This study will evaluate the efficacy, safety, and pharmacokinetics of immunotherapy-based treatment combinations in participants with metastatic non...

Active, not recruiting
Carcinoma, Non-Small-Cell Lung
Drug: Ipatasertib
Drug: XL092

This is an international, randomized, open-label, Phase 3 study designed to evaluate whether the potent and selective RET inhibitor, pralsetinib, imp...

Active, not recruiting
Neoplasms by Site
Neoplasms, Nerve Tissue
Drug: Carboplatin
Drug: Nab-Paclitaxel

The purpose of the study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab in participa...

Active, not recruiting
Non-Small Cell Lung Cancer
Drug: Tiragolumab
Drug: Atezolizumab

This study will be conducted to determine the preliminary efficacy of axatilimab in combination with ruxolitinib and to assess the contribution of ax...

Begins enrollment this month
Chronic Graft-versus-host-disease
Drug: Axatilimab
Drug: Corticosteroids

In this study, researchers will learn more about a study drug called BIIB091 in participants with MS who may be experiencing relapses. It is a 2-part...

Enrolling
Relapsing Forms of Multiple Sclerosis
Drug: BIIB091
Drug: DRF

This study will treat patients with advanced NSCLC with EGFR or HER2 mutation who have progressed following prior therapy. This is the first time thi...

Active, not recruiting
Non-Small Cell Lung Cancer
Drug: Sunvozertinib

The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6)...

Active, not recruiting
Gastric Cancer
Gastroesophageal Junction Adenocarcinoma
Drug: Bemarituzumab
Drug: mFOLFOX6

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN281...

Enrolling
Melanoma
Drug: Cemiplimab
Drug: Placebo

Phase 3, multicenter, international, open-label, randomized, 2-arm trial investigating the safety and efficacy of IO102-IO103 in combination with pem...

Active, not recruiting
Unresectable Melanoma
Metastatic Melanoma
Drug: Pembrolizumab
Drug: IO102-IO103

The purpose of this study is to assess the safety and efficacy of tulisokibart in participants with SSc-ILD.

Enrolling
Diffuse Cutaneous Systemic Sclerosis
Interstitial Lung Disease
Diagnostic Test: Companion diagnostic ( CDx)
Drug: Tulisokibart

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