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Hospital Universitario Reina Sofia | Clinical Research Unit

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Atezolizumab
Upadacitinib
Bevacizumab
ABT-494
Azacitidine
Trastuzumab
Carboplatin
Gemcitabine
Ritlecitinib
Rocatinlimab

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Active trials

72 of 169 total trials

A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

The purpose of this study is to learn about the safety and effects of the study medicine ritlecitinib for the possible treatment of nonsegmental viti...

Active, not recruiting
Stable Nonsegmental Vitiligo
Active Nonsegmental Vitiligo
Drug: Ritlecitinib
Drug: Placebo
Locations recently updated

In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE)....

Enrolling
Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus
Drug: Litifilimab
Drug: Placebo

A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents with Nonsegmental Vitiligo (Active and Stable) Tranquillo

Active, not recruiting
Stable Nonsegmental Vitiligo
Active Nonsegmental Vitiligo
Drug: Ritlecitinib
Drug: Placebo

This study is to evaluate how safe and effective ritlecitinib is in participants with non-segmental vitiligo (NSV).Ritlecitinib is studied in patient...

Enrolling
Vitiligo
Drug: Ritlecitinib
Drug: Ritlecitinib 100 mg

The purpose of this study is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of RO7507062 in participants wi...

Enrolling
Systemic Lupus Erythematosus
Drug: RO7507062
Drug: Tocilizumab

In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE)....

Invitation-only
Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus
Drug: BIIB059 (litifilimab)
Locations recently updated

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's...

Enrolling
Ulcerative Colitis Chronic
Ulcerative Colitis
Drug: Mirikizumab

The main objective of the study will be to evaluate the efficacy of rocatinlimab compared with placebo at week 24 on the patient-reported outcome (PR...

Enrolling
Prurigo Nodularis
Drug: Placebo
Drug: Rocatinlimab

This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulati...

Enrolling
Colorectal Cancer Stage III
Colorectal Cancer Stage II
Drug: RO7198457 intravenous (IV)
Other: Observational group (no intervention)

This study will evaluate the pharmacokinetics, pharmacodynamics, safety, immunogenicity, and radiological and clinical effects of subcutaneous (SC) a...

Active, not recruiting
Primary Progressive Multiple Sclerosis
Relapsing Multiple Sclerosis
Drug: Ocrelizumab SC
Drug: Dexamethasone given orally
Locations recently updated

The purpose of this study is to measure the benefit of adding abemaciclib to the chemotherapy, temozolomide, for newly diagnosed high-grade glioma fo...

Enrolling
Glioma
Drug: Abemaciclib
Drug: Temozolomide

The aim of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of filgotinib as a treatment for UC in children an...

Not yet enrolling
Ulcerative Colitis
Drug: Filgotinib

This is a Phase III, open-label, multicenter, randomized, two-arm study designed to evaluate the efficacy and safety of atezolizumab plus either lenv...

Active, not recruiting
Unresectable Hepatocellular Carcinoma
Drug: Lenvatinib
Drug: Atezolizumab

The purpose of this study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo in participants with unresect...

Active, not recruiting
Esophageal Squamous Cell Carcinoma
Drug: Atezolizumab
Drug: Atezolizumab Matching Placebo

The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refra...

Enrolling
Systemic Sclerosis
Idiopathic Inflammatory Myopathy
Drug: Fludarabine
Drug: CC-97540

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Active, not recruiting
Chronic Kidney Disease
Overweight
Drug: Orforglipron
Drug: Insulin Glargine
Recently updated

This clinical trial is studying advanced or metastatic solid tumors. Once a solid tumor has grown very large in one spot or has spread to other place...

Active, not recruiting
Ovarian Neoplasms
Carcinoma, Non-Small-Cell Lung
Drug: disitamab vedotin

This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lun...

Enrolling
Small Cell Lung Cancer
Drug: Topotecan
Drug: Amrubicin
Locations recently updated

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of th...

Enrolling
Crohn's Disease
Drug: Mirikizumab

This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Drug: Venetoclax
Drug: Azacitidine

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