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JOSHA Research | Bloemfontein, South Africa

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Top treatments

Islatravir
Doravirine
MK-8527
ISL
Bococizumab
Semaglutide
Famciclovir
nucleoside
Pimodivir
MK-8591B-062

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Active trials

13 of 59 total trials

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

Researchers are looking for new ways to treat HIV-1 (Human Immunodeficiency Virus Type 1). The usual (standard) treatment for HIV-1 is antiretroviral...

Enrolling
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Drug: ISL/ULO
Drug: ULO

This study aims to check how safe and well-tolerated a second dose of RSVpreF is when given during later pregnancies, and to see how long the immunit...

Enrolling
RSV Infection
Biological: Placebo
Biological: RSVpreF

The purpose of this study is to assess the safety and immunogenicity of mRNA-1365, an mRNA vaccine targeting respiratory syncytial virus (RSV) and hu...

Active, not recruiting
Human Metapneumovirus
Respiratory Syncytial Virus
Biological: Placebo
Biological: mRNA-1345

The purpose of this study is to evaluate the safety and tolerability of DOR/ISL in adult participants with HIV-1 who had been previously treated with...

Active, not recruiting
HIV Infection
Drug: DOR/ISL

Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection.The goals of this study are to learn:* If...

Enrolling
HIV Pre-Exposure Prophylaxis
Human Immunodeficiency Virus (HIV)
Drug: Emtricitabine/tenofovir disoproxil (FTC/TDF)
Drug: MK-8527

The purpose of this study is to test the efficacy and safety of orforglipron in participants with T2D (type 2 diabetes) who participate in fasting du...

Enrolling
Behavior
Glucagon-Like Peptide-1 Receptor
Drug: Orforglipron

The purpose of this study is to evaluate how well CD388 works in preventing symptomatic laboratory-confirmed influenza infections, as compared to pla...

Active, not recruiting
Influenza
Combination Product: CD388 Injection
Combination Product: Placebo

The primary objectives of this study are to evaluate the safety and tolerability of a switch to Doravirine/Islatravir (DOR/ISL) compared with continu...

Active, not recruiting
HIV-1 Infection
Drug: DOR/ISL
Drug: ART

BEATRIX (group B strEptococcus mATeRnal and Infant VaX study) The purpose of this study is to learn about the safety and how the group B streptococcu...

Enrolling
Healthy
Biological: Infanrix hexa
Biological: Prevnar 20

This is a randomized, active-controlled, double-blind clinical study designed to evaluate the antiretroviral activity, safety, and tolerability of do...

Active, not recruiting
HIV-1 Infection
Drug: BIC/FTC/TAF
Drug: Placebo to DOR/ISL

The safety and tolerability of MK-8591A, a 2-drug fixed dose combination (FDC) of doravirine (100mg) and islatravir (0.75mg) \[DOR/ISL 100 mg/0.75 mg...

Active, not recruiting
HIV-1 Infection
Drug: MK-8591A

This study will randomize patients recently discharged from the hospital with a confirmed diagnosis of type 1 acute myocardial infarction (Thygesen e...

Invitation-only
Acute Myocardial Infarction
Combination Product: Placebo
Combination Product: Selatogrel

Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a...

Active, not recruiting
Lower Respiratory Tract Illness
Biological: RSVpreF
Biological: Placebo

Trial sponsors

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