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JOSHA Research | Bloemfontein, South Africa

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Top conditions

Top treatments

Islatravir
Doravirine
MK-8527
ISL
Bococizumab
GRT7039
Semaglutide
nucleoside
Pimodivir
MK-8591A

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Active trials

15 of 49 total trials

A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Lower Blood Sugar in People With Type 2 Diabetes

This study will look at how well a new medicine called NNC0519-0130 helps people with type 2 diabetes lower their blood sugar and body weight. The st...

Enrolling
Diabetes Mellitus, Type 2
Drug: Trizepatide
Drug: NNC0519-0130

The purpose of this study is to assess the safety and immunogenicity of mRNA-1365, an mRNA vaccine targeting respiratory syncytial virus (RSV) and hu...

Active, not recruiting
Human Metapneumovirus
Respiratory Syncytial Virus
Biological: Placebo
Biological: mRNA-1345

The purpose of this study is to evaluate the safety and tolerability of DOR/ISL in adult participants with HIV-1 who had been previously treated with...

Active, not recruiting
HIV Infection
Drug: DOR/ISL

The purpose of the study is to evaluate the reactogenicity, safety, and immunogenicity of an investigational respiratory syncytial virus (RSV) vaccin...

Enrolling
Respiratory Syncytial Virus
Biological: Placebo
Biological: mRNA-1345

The purpose of this study is to learn about the safety and effects of sisunatovir. Sisunatovir is studied for the possible treatment of Respiratory S...

Active, not recruiting
Respiratory Syncytial Virus Infection
Drug: Placebo
Drug: Sisunatovir

The purpose of the study is to learn about the safety and immune activity of the RSVpreF vaccine. It will be studied in infants born to mothers livin...

Enrolling
Respiratory Syncytial Virus
Biological: RSVpreF vaccine
Biological: Placebp

The primary objectives of this study are to evaluate the safety and tolerability of a switch to Doravirine/Islatravir (DOR/ISL) compared with continu...

Active, not recruiting
HIV-1 Infection
Drug: DOR/ISL
Drug: ART

This is a randomized, active-controlled, double-blind clinical study designed to evaluate the antiretroviral activity, safety, and tolerability of do...

Enrolling
HIV-1 Infection
Drug: BIC/FTC/TAF
Drug: Placebo to DOR/ISL

An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in...

Active, not recruiting
Osteoarthritis
Drug: RTX-GRT7039

The safety and tolerability of MK-8591A, a 2-drug fixed dose combination (FDC) of doravirine (DOR 100mg) and islatravir (ISL 0.75mg) will be evaluate...

Active, not recruiting
HIV-1 Infection
Drug: MK-8591A

This study is an adaptive, randomized, double blind, platform trial evaluating promising investigational products (IP) for safety and efficacy as ear...

Enrolling
SARS-CoV-2
Drug: Upamostat
Drug: Placebo (PO)

This double-blind, placebo-controlled study is designed to assess the safety, tolerability, and pharmacokinetics of oral MK-8527 taken once monthly (...

Active, not recruiting
HIV
HIV Pre-exposure Prophylaxis
Drug: MK-8527
Drug: Placebo to MK-8527

This is a phase 3, randomized, controlled, double-blind, multisite clinical study of a once-daily fixed dose combination (FDC) of 100 mg doravirine/0...

Active, not recruiting
HIV-1 Infection
Drug: BIC/FTC/TAF
Drug: DOR/ISL

Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a...

Enrolling
Lower Respiratory Tract Illness
Biological: RSVpreF
Biological: Placebo
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This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with...

Enrolling
Chronic Kidney Disease
Inflammation
Drug: Placebo (Ziltivekimab B)
Drug: Placebo (Ziltivekimab C)

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