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Manassas Clinical Research Center | Manassas, VA

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MK-0616
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Active trials

15 of 87 total trials

A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

Researchers designed a study medicine called enlicitide to lower low-density lipoprotein cholesterol (LDL-C). In this study, researchers want to lear...

Enrolling
Hyperlipidemia
Drug: Placebo for Rosuvastatin
Drug: Enlicitide

The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropi...

Enrolling
Obesity or Overweight
Type 2 Diabetes Mellitus
Combination Product: Enicepatide
Combination Product: Placebo

This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tol...

Active, not recruiting
Obesity or Overweight
Drug: RO7795081
Drug: Placebo

This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of enicep...

Active, not recruiting
Type 2 Diabetes Mellitus (T2DM)
Overweight or Obese
Drug: Enicepatide
Drug: Placebo

CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c...

Active, not recruiting
Primary Prevention of Atherosclerotic Cardiovascular Disease
Drug: Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
Drug: Placebo in 1.5ml

The main purpose of this study is to assess the dose-response relationship of maridebart cafraglutide on glucose control compared with placebo.

Active, not recruiting
Type 2 Diabetes Mellitus (T2DM)
Drug: Maridebart Cafraglutide
Drug: Placebo

The main aim of the study is to assess the effect of RO7204239 in combination with tirzepatide, compared to placebo in combination with tirzepatide,...

Active, not recruiting
Overweight
Obesity
Drug: Tirzepatide
Drug: RO7204239 Matching Placebo

This multicenter, randomized, double-blind, placebo- and open-label active comparator-controlled, parallel-group, dose-range-finding, Phase II study...

Active, not recruiting
Type 2 Diabetes Mellitus
Drug: Semaglutide
Drug: Placebo

The goal of this clinical trial is to evaluate if the study drug CIN-102 (deudomperidone) can help to decrease nausea severity associated with idiopa...

Active, not recruiting
Idiopathic Gastroparesis
Drug: Placebo
Drug: CIN-102 Dose 15mg

The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at differe...

Enrolling
Hypertension
Drug: QCZ484
Other: Saline

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have...

Enrolling
Atherosclerotic Cardiovascular Disease (ASCVD)
Elevated Lp(a)
Drug: Placebo
Drug: Muvalaplin

The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.

Active, not recruiting
Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Drug: Maridebart cafraglutide
Drug: Placebo

This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/...

Active, not recruiting
Arteriosclerosis
Hypercholesterolaemia
Drug: Enlicitide Decanoate
Drug: Placebo

This is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed...

Active, not recruiting
Hypercholesterolemia
Drug: Enlicitide Decanoate

This is a Phase 2, randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Dia...

Enrolling
Type 2 Diabetes
Drug: icovamenib 100mg
Drug: Placebo

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