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MD Anderson Cancer Center Madrid | Medical Oncology Department

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Pembrolizumab
Azacitidine
Trastuzumab
Zipalertinib
Plitidepsin
Sacituzumab
Tipifarnib
Magrolimab
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Active trials

20 of 45 total trials

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

Study ASTX030-01 is a multi-phase study comprising of Phases 1-3 Monotherapy arms, and Phase 1 and Phase 2 Combination Therapy arms. Phase 1 Monother...

Enrolling
Myelodysplastic Syndrome/Neoplasm
Myelodysplastic Syndromes
Drug: ASTX030 (cedazuridine + azacitidine)
Drug: Venetoclax

This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It...

Enrolling
Urothelial Carcinoma
Drug: pembrolizumab
Drug: disitamab vedotin

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or meta...

Enrolling
Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations
Drug: TAS6417
Drug: CYP Cocktail

The purpose of this study is to compare the efficacy of zipalertinib combined with adjuvant chemotherapy versus placebo combined with adjuvant chemot...

Active, not recruiting
NSCLC, Stage IB-IIIA
Exon 20
Drug: Cisplatin
Drug: Pemetrexed

The primary objective is to define the safety and tolerability of AB8939 in patients with AML by determining the dose-limiting toxicities, the maximu...

Enrolling
Acute Myeloid Leukemia Refractory
Myelodysplastic Syndrome Acute Myeloid Leukemia
Drug: Venetoclax
Drug: AB8939

This is a multi-center, open-label study to evaluate the safety, pharmacokinetics (PK), and anti-cancer activity of oral administration of emavuserti...

Enrolling
Refractory Hematologic Malignancy
Refractory Primary Central Nervous System Lymphoma
Drug: Emavusertib
Drug: Ibrutinib

This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through th...

Active, not recruiting
Urothelial Carcinoma
Drug: cisplatin
Drug: carboplatin

The purpose of the study is to evaluate efficacy and safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide compared to target...

Active, not recruiting
Neuroendocrine Tumors
Drug: 177Lu-edotreotide PRRT
Other: Amino-Acid Solution

Researchers are looking for new ways to treat high-risk non muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the i...

Active, not recruiting
High-risk Non-muscle Invasive Bladder Cancer
Biological: Pembrolizumab
Biological: BCG

This trial will study a type of advanced breast cancer (ABC) defined as endocrine receptor (ER)-positive/human epidermal growth factor receptor 2(HER...

Enrolling
ER-positive Breast Cancer
ESR1 Gene Mutation
Drug: Everolimus
Drug: Placebo

The goal of this trial is to learn about the antibody GEN1042 when it is used alone and when it is used together with another antibody cancer drug, p...

Active, not recruiting
Colorectal Cancer (CRC)
Melanoma
Biological: GEN1042
Drug: Nab paclitaxel

The goal of this trial is to learn about the antibody acasunlimab (an antibody also known as GEN1046) when it is used alone and when it is used toget...

Active, not recruiting
Solid Tumors
Biological: Acasunlimab in combination with pembrolizumab and standard chemotherapy (in separate expansion cohorts)
Biological: Acasunlimab

DEMETHER is a phase II trial exploring the maintenance of trastuzumab and pertuzumab fixed dose combination (FDC) for subcutaneous administration (SC...

Active, not recruiting
HER2-positive Breast Cancer
Drug: Phesgo 600 MG / 600 MG / 20,000 UNT in 10 mL Injection
Drug: Phesgo 1,200 MG / 600 MG / 30,000 UNT Per 15 ML Injection

The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy...

Active, not recruiting
Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation
Drug: TAS6417

SETHY is a prospective, multicohort, phase II, single-arm, non-randomized, non-blinded, investigator-initiated study of sacituzumab govitecan in pati...

Enrolling
Differentiated Thyroid Cancer
Anaplastic Thyroid Cancer
Drug: Sacituzumab govitecan

The goal of this study is to assess the safety, tolerability, anti-tumor activity (efficacy), pharmacokinetics (PK), and pharmacodynamics (PD) of the...

Active, not recruiting
High-risk Myelodysplastic Syndrome
Acute Myeloid Leukemia (AML)
Drug: RVU120

The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinom...

Enrolling
Endometrial Cancer
Drug: Matching Placebo for selinexor
Drug: Selinexor

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men...

Active, not recruiting
Prostatic Neoplasms
Drug: Placebo
Biological: Pembrolizumab

The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) versus treatment of phy...

Active, not recruiting
Triple Negative Breast Cancer
PD-L1 Negative
Drug: Sacituzumab Govitecan-hziy
Drug: Paclitaxel

This phase 3 study will be conducted in different countries all over the world.The purpose of this study is to compare how well Rina-S works against...

Active, not recruiting
Platinum-resistant Ovarian Cancer
Drug: Topotecan
Drug: Gemcitabine

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