Medisch Spectrum Twente | Thorax Centrum Twente - Foundation Cardiovascular Research and Education Enschede

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Koningsplein 1, Enschede, Overijssel, Netherlands

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Active trials

29 of 218 total trials
Locations recently updated

A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433 (U-ENDURE)

A multicenter study to evaluate the efficacy and safety of maintenance and long-term treatment administration of upadacitinib, an orally administered...

Active, not recruiting
Crohn's Disease
Drug: Placebo for Upadacitinib
Drug: Upadacitinib

This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the...

ST-elevation Myocardial Infarction (STEMI)
Drug: Placebo
Drug: zalunfiban

This is a Phase 3 double-blind, placebo-controlled, randomized study designed to investigate whether tafasitamab and lenalidomide as an add-on to rit...

Active, not recruiting
Marginal Zone Lymphoma
Follicular Lymphoma
Drug: rituximab
Drug: placebo

This randomized controlled trial will outline the advantages and disadvantages of the subcutaneous implantable cardioverter defibrillator (ICD) compa...

Active, not recruiting
Ventricular Arrhythmias
Device: Implantation of subcutaneous ICD
Device: Implantation of transvenous ICD
Locations recently updated

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get z...

Heart Failure
Drug: Placebo
Drug: Ziltivekimab

This study is comparing 200 milligrams (mg) of filgotinib a day with a placebo to see if filgotinib helps to treat Axial Spondyloarthritis (axSpA) an...

Active, not recruiting
Axial Spondyloarthritis
Drug: Placebo
Drug: Filgotinib

The purpose of this study is to assess if adding LY3537982 in combination with standard of care anti-cancer drugs is more effective than standard of...

Carcinoma, Non-Small-Cell Lung
Neoplasm Metastasis
Drug: Carboplatin
Drug: LY3537982

The main purpose of this study is to determine the efficacy and safety of LY3819469 in adults with elevated lipoprotein(a). The study will lasts abou...

Active, not recruiting
Lipoprotein Disorder
Drug: Placebo
Drug: LY3819469

The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major advers...

Acute Coronary Syndrome
Other: Placebo
Drug: Milvexian

B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of t...

Diffuse Large B-Cell Lymphoma
Drug: Epcoritamab
Drug: Rituximab

Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the...

High-risk Transient Ischemic Attack
Acute Non-cardioembolic Ischemic Stroke
Drug: Asundexian (BAY2433334)
Drug: Placebo

The purpose of this study is to establish the safety and effectiveness of the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device, including the po...

Active, not recruiting
Drug: Single Antiplatelet Therapy or No Therapy (Control)
Device: WATCHMAN LAAC Device Implant

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in p...

Invasive Procedure
Drug: Bentracimab (PB2452) Infusion

The clinical significance of pulmonary embolism (PE) limited to the subsegmental pulmonary arteries, so called isolated subsegmental pulmonary emboli...

Venous Thromboembolism
Pulmonary Embolism
Drug: Rivaroxaban
Drug: Placebo

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Ph...

Ischemic Heart Disease
Coronary Artery Disease
Device: Philips SyncVision system with Philips pressure wires
Procedure: standard of care angiographically-guided PCI

Background: Intracerebral hemorrhage (ICH) accounts for 16-19% of all strokes in Western Europe and contributes profoundly to mortality and disabilit...

Minimally Invasive Surgical Procedures
Endoscopic Surgical Procedures
Device: Minimally invasive endoscopy-guided surgery

The objective of the study is to assess the stent stability and durability as well as the seal of the stent graft during the cardiac cycle and over t...

Vascular Aneurysm
Diagnostic Test: ECG-gated CTAs

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults wi...

Active, not recruiting
Coronary Heart Disease (CHD)
Drug: Evolocumab
Drug: Placebo

Rationale:Permanent cardiac pacing is the only available therapy in patients with atrioventricular (AV) conduction disorders and can be life-saving....

Left Ventricular Septal Pacing
Atrioventricular Block
Procedure: Left ventricular septal pacing
Procedure: Right ventricular pacing

This is an international (Australia, Europe, and USA) open-label two-arm randomized phase 3 trial including 420 stage III (≤3 resectable in-transit m...

Active, not recruiting
Malignant Melanoma Stage III
Drug: Adjuvant nivolumab
Drug: Neoadjuvant ipilimumab + nivolumab

Trial sponsors

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