Memorial Sloan-Kettering Cancer Center | MSK Department of Medicine, Gastrointestinal Research

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Active trials

11 of 60 total trials

A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)

A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients with Relapsed/Refracto...

AML, Adult Recurrent
Drug: Decitabine
Drug: LYT-200

This study is an open-label, multi-center, dose-escalation, dose expansion study in adult subjects with advanced solid tumors. The study will evaluat...

Active, not recruiting
Non-small Cell Lung Cancer
Castration-resistant Prostate Cancer
Drug: SM08502
Drug: Prednisone

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer...

Active, not recruiting
Urothelial Cancer
Drug: Erdafitinib
Drug: Docetaxel

The purpose of the study is to assess the safety, tolerability, and efficacy of farletuzumab ecteribulin (MORAb-202) and compare it to Investigator's...

Neoplasms, Ovarian
Drug: Topotecan
Drug: Paclitaxel

Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or me...

Locally Advanced Solid Tumors
Primary CNS Tumors
Drug: Oral repotrectinib (TPX-0005)

The purpose of this study is to confirm the recommended phase 2 dose (RP2D) of zolbetuximab in combination with Nab-P + GEM, determine overall surviv...

Active, not recruiting
Metastatic Pancreatic Adenocarcinoma
Metastatic Pancreatic Cancer
Drug: nab-paclitaxel
Drug: gemcitabine

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell tr...

Active, not recruiting
Multiple Myeloma
Drug: Lenalidomide
Drug: Iberdomide

Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patie...

Active, not recruiting
Hand-Foot Skin Reaction (HFSR)
Drug: OQL011
Drug: Vehicle Ointment

This study is open to adults with advanced cancer in the biliary tract, pancreas, lung, or bladder. This is a study for people for whom previous trea...

Lung Neoplasms
Bladder Cancer
Drug: brigimadlin

The purpose of this study is to determine the safety, tolerability, and the maximum tolerated dose/recommended phase II dose of carboxyamidotriazole...

Active, not recruiting
Solid Tumors, Glioblastoma, Recurrent Malignant Gliomas
Drug: CTO and Temodar®
Drug: CTO

This is a multicenter Phase 3 clinical study, which aims to evaluate the effectiveness of an investigational drug called vimseltinib for the treatmen...

Active, not recruiting
Tenosynovial Giant Cell Tumor, Diffuse
Giant Cell Tumor of Tendon Sheath
Drug: Placebo
Drug: vimseltinib

Trial sponsors

Celgene logo
Medical College of Wisconsin logo
Bristol-Myers Squibb (BMS) logo
Acrotech Biopharma logo
Bayer logo
Boehringer Ingelheim logo
Memorial Sloan Kettering Cancer Center (MSK) logo
National Cancer Institute (NCI) logo
National Institutes of Health (NIH) logo
Pfizer logo

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