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Mid-Atlantic Epilepsy and Sleep Center | Bethesda, MD

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Top conditions

Top treatments

XEN1101
Cenobamate
Eslicarbazepine Acetate
YKP3089
Retigabine
ZX008
Ganaxolone
Perampanel
LP352
Fenfluramine Hydrochloride

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Active trials

15 of 45 total trials

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE2)

The X-TOLE2 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and toler...

Enrolling
Focal Onset Seizures
Drug: XEN1101
Drug: Placebo

The XEN1101 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and toler...

Active, not recruiting
Focal Epilepsy
Drug: XEN1101

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN...

Enrolling
Primary Generalized Tonic-Clonic Seizures
Drug: XEN1101
Drug: Placebo

This is an international, multicenter, open-label, long-term safety study of ZX008 in subjects with Dravet syndrome, Lennox-Gastaut syndrome or epile...

Active, not recruiting
Epileptic Encephalopathy
Dravet Syndrome
Drug: ZX008 (Fenfluramine Hydrochloride)

Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the...

Enrolling
High-risk Transient Ischemic Attack
Acute Non-cardioembolic Ischemic Stroke
Drug: Asundexian (BAY2433334)
Drug: Placebo

This study will evaluate the long term safety, tolerability, PK, and efficacy of XEN1101 25 mg QD taken orally in subjects with Focal Onset Seizures...

Invitation-only
Tonic-Clonic Seizures
Focal Epilepsy
Drug: XEN1101

52 Week Open-Label Safety Study of Cenobamate for Subjects who Complete YKP3089C025 (core study)

Invitation-only
Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy
Drug: Cenobamate
Locations recently updated

The primary objective of this study is to assess the pharmacokinetics of cenobamate (YKP3089) in pediatric subjects with partial-onset (focal) seizur...

Enrolling
Partial Epilepsy
Drug: Xcopri

Study RAD-GRIN-101 is a phase 1B trial to assess safety, tolerability, PK, and potential efficacy of radiprodil for the treatment of GRIN-related dis...

Active, not recruiting
GRIN-related Disorders
Drug: Radiprodil

The primary objective is to evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the number of drop seizures (tonic, ato...

Enrolling
Seizures
Lennox Gastaut Syndrome
Drug: Carisbamate

This is a Phase 3, global, open-label extension (OLE) study of adjunctive GNX treatment in children and adults with TSC who previously participated i...

Invitation-only
Tuberous Sclerosis Complex
Drug: Ganaxolone

The objective of this study is to assess the long-term safety, tolerability, and efficacy of adjunctive therapy of LP352 in subjects with development...

Active, not recruiting
Developmental and Epileptic Encephalopathy
Lennox-Gastaut Syndrome
Drug: LP352, bexicaserin

This trial is intended to study the safety and effectiveness of an new anti-epileptic drug (AED) on Primary Generalized Tonic-Clonic (PGTC) Seizures....

Enrolling
Primary Generalized Epilepsy
Drug: Cenobamate
Drug: Placebo
Locations recently updated

Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures

Enrolling
Partial Epilepsy
Drug: Xcopri

This is a double-blind, placebo controlled, randomized study of dose-ranging safety, tolerability, exploratory efficacy of adjunctive EQU-001 for sei...

Active, not recruiting
Epilepsy
Drug: Placebo
Drug: EQU-001

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