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Midwest Cardiovascular Institute | Naperville, IL

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CK-1827452
Ziltivekimab
Apixaban
Omecamtiv Mecarbil

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Active trials

9 of 14 total trials

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get z...

Enrolling
Heart Failure
Drug: Placebo
Drug: Ziltivekimab

The purpose of this study is to evaluate if milvexian is at least as effective as apixaban for reducing the risk of the composite stroke and non-cent...

Active, not recruiting
Atrial Fibrillation
Drug: Apixaban Placebo
Drug: Milvexian

Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneousl...

Invitation-only
Heart Failure
Other: Sham-Control
Device: Alleviant ALV1 System

The purpose of this research study is to evaluate whether using the the IMPELLA® CP System temporary circulatory assist device for 30 minutes prior t...

Active, not recruiting
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Device: Impella CP® placement prior to reperfusion with Primary PCI

The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improv...

Active, not recruiting
Heart Failure
Other: Control
Device: V-Wave Interatrial Shunt

The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following po...

Enrolling
Atrial Fibrillation
Stroke
Device: WATCHMAN FLX Pro LAAC Device

The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, l...

Enrolling
Heart Failure With Reduced Ejection Fraction
Heart Failure
Drug: Placebo
Drug: Omecamtiv Mecarbil (OM)

The CLAAS® device will be evaluated for safety and efficacy by establishing its performance is non-inferior to the commercially available WATCHMAN® a...

Enrolling
Atrial Fibrillation
Stroke
Device: CLAAS
Device: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in t...

Enrolling
Heart Valve Diseases
Mitral Valve Insufficiency
Other: Guideline Directed Heart Failure Medication
Device: Carillon Mitral Contour System

Trial sponsors

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