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Minneapolis Heart Institute Foundation | Minneapolis, MN

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Active trials

29 of 122 total trials

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events (TRANSFORM)

TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for athero...

Enrolling
Diabetes Mellitus, Type 2
Metabolic Syndrome
Device: The Cleerly CAD Staging System

The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic...

Active, not recruiting
Cardiomyopathy, Hypertrophic
Drug: Mavacamten
Other: Placebo

To test whether FFRangio-guided treatment is non-inferior to conventional pressure wire-guided treatment in patients with coronary artery disease.

Active, not recruiting
Percutaneous Coronary Intervention
Device: FFR or NHPR
Device: FFRangio

Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneousl...

Invitation-only
Heart Failure
Other: Sham-Control
Device: Alleviant ALV1 System

This is a prospective, single arm, multicenter, clinical trial designed to evaluate the safety and performance of the AltaValve System for the treatm...

Enrolling
Mitral Incompetence
Mitral Valve Regurgitation
Device: AltaValve System.

Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Rest...

Enrolling
Dilated Cardiomyopathy
Heart Failure With Reduced Ejection Fraction (HFrEF)
Device: AccuCinch Ventricular Restoration System
Drug: Guideline-Directed Medical Therapy

The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of symptomatic severe tricusp...

Enrolling
Tricuspid Valvular Disorders
Tricuspid Valve Disease
Device: VDyne Transcatheter Tricuspid Valve Replacement System

The purpose of this study is to demonstrate substantial equivalence in terms of safety to support an indication change related to the usage of Preven...

Enrolling
Orthopedic Surgery
Vascular Surgery
Device: Prevena Plus Incision Management System with Prevena Dressings

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults wi...

Active, not recruiting
Coronary Heart Disease (CHD)
Drug: Evolocumab
Drug: Placebo

To demonstrate the safety and effectiveness of the Shockwave Reducer for treatment of patients with refractory angina pectoris treated with maximally...

Enrolling
Refractory Angina
Device: Arm 3 (unblinded, non-randomized): Single arm registry
Other: Arm 2 (control): Implantation procedure with no device implanted

The purpose of this trial is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft Systems verses Gore Exc...

Enrolling
Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder)
Abdominal Aortic Aneurysm
Device: Gore Excluder or Gore/ Excluder Conformable AAA Endoprosthesis
Device: Medtronic Endurant II or Endurant IIs Stent Graft System

The aim of the TARGET-IV NA trial is to demonstrate the clinical non-inferiority of the Firehawk® rapamycin eluting stent system in comparison to cur...

Active, not recruiting
Coronary Artery Disease
Device: 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)
Device: Microport Firehawk stent

The LEADR study is designed to assess the safety and efficacy of the Next Generation ICD lead.The LEADR LBBAP study is being conducted under the exis...

Active, not recruiting
Tachyarrhythmia
Device: Defibrillation (RV Implant)
Device: Defibrillation (LBBAP Implant)

A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coa...

Enrolling
Coronary Artery Disease
In-Stent Restenosis
Device: Plan balloon Angioplasty (POBA)
Device: Sirolimus Drug Coated Balloon

This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatmen...

Enrolling
Coronary Artery Disease
Native Coronary Artery Stenosis
Device: Sirolimus Drug Coated Balloon
Device: Drug eluting stents (DES)

The primary objective of this study is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (C...

Active, not recruiting
Atherosclerotic Cardiovascular Disease
Drug: Olpasiran
Drug: Placebo

To evaluate the safety and effectiveness of the Model 400 aortic valve bioprosthesis.

Active, not recruiting
Aortic Stenosis
Device: Model 400 aortic valve bioprosthesis

This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single...

Enrolling
Congestive Heart Failure
Drug: AB-1002

This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynam...

Enrolling
Coronary Artery Disease
Device: Percutaneous Mechanical Circulatory Support

This is a prospective, open- label, single arm, multicenter clinical trial to evaluate the safety and effectiveness of the Cordella PA Sensor System...

Active, not recruiting
Heart Failure NYHA Class III
Device: Cordella™ Pulmonary Artery Sensor System

Trial sponsors

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Medtronic logo
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Boehringer Ingelheim logo
Bristol-Myers Squibb (BMS) logo

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