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Active trials

110 of 214 total trials
Locations recently updated

A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9

The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of...

Enrolling
Advanced Solid Cancers
Drug: BNT329
Drug: CA19-9-targeting monoclonal antibody

To evaluate the feasibility and safety of the Millipede Transcatheter Annuloplasty Ring System in subjects with functional mitral regurgitation

Active, not recruiting
Mitral Valve Disease
Cardiovascular Diseases
Device: Millipede Transcatheter Annuloplasty Ring System (Millipede System)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-...

Enrolling
Advanced Solid Tumor
Drug: Anticancer Agents
Drug: BG-C137

This is a Phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, and DLTs to establish the maximum tolerated dose (M...

Enrolling
Locally Advanced Unresectable or Metastatic Solid Tumors
Biological: IBI354

The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients w...

Enrolling
Relapsed/Refractory Multiple Myeloma
Drug: Pomalidomide
Drug: Carfilzomib

This is a 3-part Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, zovegalisib (RLY-2608), in adul...

Enrolling
Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)
Klippel Trenaunay Syndrome
Drug: Placebo
Drug: RLY-2608

The purpose of this protocol is to evaluate the efficacy (how well it works), safety and tolerability of oral icotrokinra as therapy in adult and ado...

Enrolling
Colitis, Ulcerative
Drug: Icotrokinra
Drug: Placebo

To compare efficacy between zanubrutinib versus bendamustine and rituximab in patients with previously untreated CLL/SLL, as measured by progression...

Active, not recruiting
Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Drug: Rituximab
Drug: Venetoclax

The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carbop...

Enrolling
KRAS G12C Lung Cancer
Non-Small Cell Lung Cancer
Drug: Cisplatin
Drug: Pemetrexed

The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of atumelnant treatment in pediatric...

Enrolling
Classic Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia
Drug: Atumelnant
Drug: Placebo

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod...

Enrolling
Colitis, Ulcerative
Drug: Ozanimod

This is a Phase 1b/2 study to investigate the efficacy and safety of alcestobart (LBL-007) plus tislelizumab when administered in combination with be...

Active, not recruiting
Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
Drug: Alcestobart
Drug: Bevacizumab or Bevacizumab biosimilar

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse....

Active, not recruiting
Cytochrome P-450
Antineoplastic Agents, Hormonal
Drug: Placebo for Abemaciclib
Drug: Abiraterone

This study is to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamic (PD), and preliminary efficacy of ARC-02.

Enrolling
B-cell Non Hodgkin Lymphoma
Drug: ARC-02
Drug: Rituximab

The study will determine the safety, tolerability, recommended Phase 2 dose (RP2D) and preliminary efficacy of BGB-11417 as monotherapy and in combin...

Enrolling
Myelodysplastic Syndromes
Myelodysplastic/Myeloproliferative Neoplasm
Drug: BGB-11417
Drug: Azacitidine

CLN-619-001 is a Phase 1, open-label, multi-center study of CLN-619 alone and in combination with pembrolizumab in patients with advanced solid tumor...

Active, not recruiting
Advanced Solid Tumor
NSCLC
Drug: CLN-619
Drug: Datopotamab deruxtecan-dlnk (Dato-DXd)

The goal of this clinical trial is to find out about the safety, efficacy, and tolerability of DM001 for patients with the advanced solid tumors. DM0...

Enrolling
Solid Carcinoma
Carcinoma, Non-Small-Cell Lung
Drug: DM001

The purpose of this study is to evaluate two study medicines (encorafenib plus cetuximab) taken alone or together with standard chemotherapy for the...

Active, not recruiting
Neoplasms
Drug: Cetuximab
Drug: Oxaliplatin

The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with moderately to severely active ulcerative colitis...

Active, not recruiting
Ulcerative Colitis
Drug: Guselkumab
Drug: Placebo

The purpose of this study is to evaluate the efficacy, including clinical remission of guselkumab subcutaneous (SC) induction compared to placebo in...

Active, not recruiting
Colitis, Ulcerative
Drug: Guselkumab Dose 2
Other: Placebo

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