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Munson Medical Center | Cancer Research Department

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Active trials

20 of 429 total trials

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

The main purpose of the study is to examine if periadjuvant (neoadjuvant, then adjuvant) immunotherapy will prolong event free survival in participan...

Active, not recruiting
Carcinoma, Non-Small-Cell Lung
Biological: Nivolumab
Drug: Cisplatin

The AMPLATZER Muscular VSD Occluder was approved by the US Food and Drug Administration (FDA) in September, 2007. This study is designed to further e...

Active, not recruiting
Ventricular Septal Defects
Device: Muscular VSD Occluder device implantation (AMPLATZER Muscular VSD Occluder)

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor D...

Enrolling
Stage III Colon Cancer
Drug: mFOLFOX6 3-6 month
Device: Signatera test

The objective of the DISTALS Study is to evaluate the safety and effectiveness of the Tigertriever 13 Revascularization Device in restoring blood flo...

Enrolling
Ischemic Stroke
Neovascularization
Device: Tigertriever 13

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults wi...

Active, not recruiting
Coronary Heart Disease (CHD)
Drug: Evolocumab
Drug: Placebo

This randomized phase III trial studies enzalutamide to see how well it works compared to enzalutamide, abiraterone, and prednisone in treating patie...

Active, not recruiting
Hormone-resistant Prostate Cancer
Stage IV Prostate Cancer
Drug: prednisone
Drug: enzalutamide

This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several...

Enrolling
KRAS G12C Mutation
PI3K Gene Mutation
Drug: Entrectinib
Drug: PI3K Inhibitor paxalisib

This randomized phase III trial compares ixazomib citrate, lenalidomide, dexamethasone and zoledronic acid with zoledronic acid alone to see how well...

Active, not recruiting
Solitary Osseous Plasmacytoma
Drug: dexamethasone
Drug: lenalidomide

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of es...

Active, not recruiting
Breast Cancer
Drug: Letrozole
Other: Placebo

This randomized phase I/II trial studies the side effects and best dose of pomalidomide and ixazomib when given together with dexamethasone and to se...

Active, not recruiting
Multiple Myeloma in Relapse
Drug: ixazomib
Drug: dexamethasone

This phase III trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment o...

Enrolling
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Biological: Pembrolizumab
Biological: Ramucirumab

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and...

Active, not recruiting
Colorectal Neoplasms
Drug: eflornithine & sulindac placebo
Drug: Eflornithine placebo & sulindac placebo

The purpose of this study is to compare overall survival in newly diagnosed metastatic prostate cancer patients randomly assigned to androgen depriva...

Active, not recruiting
Prostate Cancer
Drug: Bicalutamide
Drug: TAK-700

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenan...

Enrolling
Multiple Myeloma
Drug: Lenalidomide
Drug: Daratumumab/rHuPH20

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in pa...

Enrolling
Prognostic Stage IA Breast Cancer AJCC v8
Prognostic Stage IB Breast Cancer AJCC v8
Other: Questionnaire Administration
Other: Quality-of-Life Assessment

This phase II trial tests whether mosunetuzumab and/or polatuzumab vedotin helps benefit patients who have received chemotherapy (fludarabine and cyc...

Enrolling
Grade 3b Follicular Lymphoma
Transformed Marg Zone Lymph to Diff Large B-Cell Lymphoma
Drug: Cyclophosphamide
Other: Patient Observation
Recently updated

This phase III trial studies olaparib or cediranib maleate and olaparib to see how well they work compared with standard platinum-based chemotherapy...

Active, not recruiting
Recurrent Primary Peritoneal Carcinoma
Ovarian Undifferentiated Carcinoma
Drug: Gemcitabine
Drug: Cediranib Maleate

prospective, non-randomized, multi-center, international clinical study is designed to confirm the safety and effectiveness of the Aveir LP System in...

Active, not recruiting
Bradycardia
Cardiac Rhythm Disorder
Device: Aveir VR Leadless Pacemaker System

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hyperte...

Active, not recruiting
Hypertension
Cardiovascular Diseases
Procedure: Renal Angiogram
Device: Paradise Renal Denervation System

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with me...

Enrolling
Recurrent Meningioma
NF2 Gene Mutation
Drug: Abemaciclib
Drug: Vismodegib

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