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National University Hospital | Gastroenterology and Hepatology Department

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Medical Centre Level 14, 1 Lower Kent Ridge Road, Singapore, Singapore, Singapore
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Trials

89 of 574
Status: Active
Trial type: Interventional
Funder type: Industry

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Locations recently updated
A C5 Inhibitor-controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Are Complement Inhibitor Treatment-Naive or Have Not Recently Received Complement Inhibitor Therapy (ACCESS-1)

The study is researching a clinical treatment combination with two experimental drugs called pozelimab and cemdisiran. The study is focused on patien...

Enrolling
Paroxysmal Nocturnal Hemoglobinuria
Drug: Eculizumab
Drug: Pozelimab

Researchers are looking for a better way to treat people who have advanced solid tumors. Advanced solid tumors are solid cancers that may have spread...

Enrolling
Advanced Solid Tumors
Drug: Pembrolizumab
Drug: BAY3375968

This is a Phase 1/2 open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of...

Enrolling
Solid Tumor
Hepatocellular Carcinoma Recurrent
Drug: Tyrosine kinase inhibitor One
Drug: OTX-2002

This study will compare the efficacy and safety of HLX04-O administered by intravitreal injection (IVT) with ranibizumab in patients with active wAMD.

Enrolling
Age Related Macular Degeneration
Drug: HLX04-O
Drug: ranibizumab

This is an open label, lead in phase Ib dose confirmation study in patients with advanced solid tumors, followed by a phase II single arm study as ne...

Enrolling
Advanced Solid Tumor
HER2-negative Breast Cancer
Drug: Paclitaxel
Drug: ADG106

A study designed to evaluate the non-inferiority of crovalimab compared with eculizumab in participants with PNH who have not been previously treated...

Active, not recruiting
Paroxysmal Nocturnal Hemoglobinuria
Drug: Eculizumab
Drug: Crovalimab

The coprimary objectives of the study are to:evaluate the efficacy of rocatinlimab in combination with topical corticosteroid and/or topical calcineu...

Enrolling
Atopic Dermatitis
Other: Placebo
Drug: Rocatinlimab

The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active pso...

Active, not recruiting
Psoriatic Arthritis
Biological: Risankizumab
Biological: Placebo

A study designed tocompare progression-free survival (PFS) in participants with t(11;14)-positive MM treated with venetoclax in combination with dexa...

Active, not recruiting
Multiple Myeloma
Drug: Dexamethasone
Drug: Pomalidomide

The main objectives of this study are to evaluate the safety and tolerability of bemarituzumab in combination with other anti-cancer therapies, and t...

Enrolling
Gastroesophageal Junction Cancer
Gastric Cancer
Drug: Nivolumab
Drug: SOX
Locations recently updated

This Phase III, randomized, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus everolimus compared with the phy...

Enrolling
Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer
Drug: Dexamethasone Mouth Rinse
Drug: LHRH Agonist

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) st...

Enrolling
Hypertension
Familial Primary Pulmonary Hypertension
Drug: Ralinepag
Drug: Placebo

Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Ph...

Invitation-only
Hypertension
Familial Primary Pulmonary Hypertension
Drug: Ralinepag
Locations recently updated

A study designed to evaluate the safety of crovalimab with eculizumab in participants with PNH currently treated with complement inhibitors. This stu...

Enrolling
Paroxysmal Nocturnal Hemoglobinuria
Drug: Crovalimab
Drug: Eculizumab

This is a Phase 3, randomized, multinational, double-blind, dual placebo-controlled, 4-arm study evaluating rucaparib and nivolumab as maintenance tr...

Active, not recruiting
FIGO Stage III-IV
Newly Diagnosed
Drug: Rucaparib
Drug: Placebo Oral Tablet

This is an open-label, multicenter, extension study. Patients who are receiving clinical benefit from atezolizumab monotherapy or atezolizumab in com...

Enrolling
Cancer
Drug: Niraparib
Drug: Pembrolizumab

IMPAHCT: Inhaled iMatinib Pulmonary Arterial Hypertension Clinical Trial is a Phase 2b/Phase 3 study to evaluate the safety and efficacy of AV-101 (d...

Enrolling
Pulmonary Arterial Hypertension
Drug: Placebo
Drug: AV-101

This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or...

Active, not recruiting
Chronic Graft-versus-host-disease
Drug: Axatilimab

This is a Phase 3 Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

Enrolling
Chronic Kidney Disease
Secondary Hyperparathyroidism
Drug: Etelcalcetide

A phase 3 study to demonstrate whether lorlatinib given as monotherapy is superior to crizotinib alone in prolonging the progression-free survival in...

Active, not recruiting
Carcinoma, Non-Small-Cell Lung
Drug: Crizotinib
Drug: Lorlatinib

Trial conditions

Breast Cancer (39 trials)
Non-Small-Cell Lung Carc... (39 trials)
Carcinoma (31 trials)
Lung Cancer (30 trials)
Stomach Cancer (18 trials)
Cancer (17 trials)
Hepatocellular Carcinoma (15 trials)
Multiple Myeloma (15 trials)
Stroke (15 trials)
Plasma Cell Cancer (14 trials)

And 90 more

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