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Optimed Research, LTD | The Boster Center for Multiple Sclerosis

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SAR441344
Ocrelizumab
Tolebrutinib
Orelabrutinib
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BIIB091
SAR442168
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Active trials

7 of 11 total trials

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the effic...

Enrolling
Multiple Sclerosis (MS) Primary Progressive
Drug: Orelabrutinib
Drug: Placebo
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Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the effic...

Enrolling
Secondary Progressive Multiple Sclerosis
Drug: Placebo
Drug: Orelabrutinib

This is a Phase 3 extension, global, multicenter study to assess the long-term safety and tolerability of tolebrutinib in adult participants (aged ≥1...

Active, not recruiting
Secondary Progressive Multiple Sclerosis
Relapsing Multiple Sclerosis
Drug: Teriflunomide
Drug: Placebo

The main objectives of the study are to demonstrate pharmacokinetics (PK) similarity between ABP 692 and Ocrelizumab (US), and ABP 692 and Ocrelizuma...

Active, not recruiting
Relapsing-remitting Multiple Sclerosis (RRMS)
Drug: Ocrelizumab (EU)
Drug: Ocrelizumab (US)

The purpose of each study is to independently measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral do...

Active, not recruiting
Multiple Sclerosis
Drug: Activated charcoal
Drug: Cholestyramine

The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the dis...

Active, not recruiting
Multiple Sclerosis
Drug: Frexalimab
Drug: Placebo

This is a randomized, open-label, parallel, Phase 3 study with 2-arms for treatment.The purpose of this study is to evaluate SC administration of fre...

Enrolling
Multiple Sclerosis
Drug: Frexalimab
Drug: MRI contrast-enhancing preparations

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