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Orange County Research Center | Lake Forest , CA

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Maridebart Cafraglutide
Plozasiran
PF-07328948
GBT021601
Orforglipron
PF-07261271
AMG 691
LY3537982
AMG 378
Tirzepatide

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Active trials

18 of 34 total trials

A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma

The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses i...

Enrolling
Asthma
Drug: Placebo
Drug: AMG 691
Locations recently updated

This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tol...

Enrolling
Obesity or Overweight
Drug: RO7795081
Drug: Placebo

The main purpose of this study is to see how well and how safely bimagrumab, tirzepatide, and the combination, work in lowering body weight in partic...

Active, not recruiting
Overweight
Obesity
Drug: Bimagrumab Placebo
Drug: Tirzepatide Placebo

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Active, not recruiting
Chronic Kidney Disease
Overweight
Drug: Orforglipron
Drug: Insulin Glargine

The main purpose of this study is to assess the dose-response relationship of maridebart cafraglutide on glucose control compared with placebo.

Active, not recruiting
Type 2 Diabetes Mellitus (T2DM)
Drug: Maridebart Cafraglutide
Drug: Placebo

The main purpose of this study is to assess how olomorasib gets into the blood stream and how long it takes the body to remove it when administered t...

Enrolling
Healthy
Hepatic Insufficiency
Drug: Olomorasib

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihy...

Active, not recruiting
Hypertension
Drug: Tonlamarsen
Drug: Placebo

The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults.Participants will receive either:* an exp...

Enrolling
Streptococcus Pneumoniae
Biological: PG4 in Buffer 1 with low dose PA-002
Biological: 20-valent pneumococcal conjugate vaccine

The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together.This study is seeking healthy...

Enrolling
COVID-19 (Coronavirus Disease 2019)
Influenza
Biological: Licensed Influenza Vaccine 2
Biological: Licensed Influenza Vaccine 1

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (H...

Enrolling
Heart Failure
Drug: Medium Dose PF-07328948
Drug: Placebo
Locations recently updated

This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People ca...

Enrolling
Heart Failure
Drug: Placebo matching vicadrostat
Drug: Empagliflozin

This a phase 1, open label, single dose, parallel cohort study to determine the pharmacokinetics (PK) of study drug (ESK-001) in healthy volunteer pa...

Enrolling
Hepatic Impairment
Drug: ESK-001
Locations recently updated

The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of car...

Enrolling
Overweight
Atherosclerotic Cardiovascular Disease
Drug: Maridebart Cafraglutide
Drug: Placebo

This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with hypertriglyceridemia (HTG). A...

Active, not recruiting
Hypertriglyceridemia
Drug: Placebo
Drug: Plozasiran Injection

The main objective of the study is to assess the safety and tolerability of AMG 378 as single or multiple doses in healthy participants.

Enrolling
Healthy Volunteers
Drug: AMG 378
Drug: Placebo

The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.

Enrolling
Cardiometabolic Disease
Drug: Placebo
Drug: AMG 513

This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (...

Active, not recruiting
Severe Hypertriglyceridemia
Drug: Plozasiran Injection
Drug: Placebo

This is a Phase 2 dose-titration study designed to evaluate the safety and efficacy of MANP subcutaneous injection compared to placebo in reducing ba...

Enrolling
Difficult to Control Hypertension
Drug: MANP
Other: Placebo Matched control

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