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Orchard Healthcare Research Inc. | Skokie, IL

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Pembrolizumab
Sacituzumab
Lenalidomide
Capecitabine
CB-839
Magrolimab
Palonosetron
Docetaxel
Azacitidine
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Active trials

26 of 54 total trials

A Phase 3 Study of Rusfertide in Patients With Polycythemia Vera (VERIFY)

The study is designed to evaluate the safety and efficacy of rusfertide in subjects with polycythemia vera (PV) in maintaining hematocrit control and...

Active, not recruiting
Polycythemia Vera
Drug: Placebo
Drug: Rusfertide

This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned.The aim is to find...

Enrolling
Non-Small Cell Lung Cancer
Drug: Cemiplimab
Drug: REGN7075

This study is to assess the pharmacokinetics (PK) and safety of SC MK-3475A vs intravenous (IV) pembrolizumab, administered with chemotherapy in firs...

Active, not recruiting
Metastatic Non-small Cell Lung Cancer
Biological: Pembrolizumab
Drug: Nab-paclitaxel

This is a Phase I/II, multicenter, open-label study to evaluate the safety, efficacy, tolerability, and pharmacokinetics of a novel BTK inhibitor, Or...

Active, not recruiting
Part 2:B-cell Malignancies
Part 1:r/r B-cell Malignancies
Drug: Orelabrutinib (ICP-022)

This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXD) in the following tumor types: endometrial cancer (EC); head...

Enrolling
Recurrent or Metastatic Solid Tumors
Drug: Ifinatamab deruxtecan

The primary objectives of the study are: (1) in the dose-escalation part: to evaluate safety and tolerability and to determine the recommended Phase...

Enrolling
Solid Tumor
Drug: Prednisone
Drug: Farletuzumab ecteribulin
Locations recently updated

The purpose of this study is to learn about the safety and how effective the study medicine (PF-07220060) plus fulvestrant is compared to the study d...

Enrolling
Advanced or Metastatic Breast Cancer
Drug: Everolimus
Drug: Fulvestrant

The phase 3 study is to compare the efficacy and safety of palonosetron, a long-acting 5-HT3 receptor antagonist, by buccal film delivery compared to...

Enrolling
Chemotherapy-induced Nausea and Vomiting
Drug: Palonosetron HCl Buccal Film 0.5 mg
Drug: IV Palonosetron 0.25 mg
Locations recently updated

The purpose of the study is to compare the efficacy and safety of Luspatercept vs epoetin alfa in the treatment of anemia in adults due to IPSS-R ver...

Enrolling
Myelodysplastic Syndromes
Biological: Epoetin Alfa
Biological: Luspatercept

This is a prospective, two arm, international, multicenter, randomized, open-label Phase III study evaluating the addition of 2 years of palbociclib...

Active, not recruiting
Breast Cancer
Drug: Standard Adjuvant Endocrine Therapy
Drug: Palbociclib

This study will compare the efficacy of the investigational agent sitravatinib in combination with nivolumab versus docetaxel in patients with advanc...

Active, not recruiting
Metastatic Non-Squamous Non-Small Cell Lung Cancer
Drug: Sitravatinib
Drug: Docetaxel

This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (sac-TMT; MK-2870) in combination with p...

Enrolling
Triple-Negative Breast Cancer
Biological: sac-TMT
Biological: Pembrolizumab
Locations recently updated

This study is a Phase II, multi-site, randomized, open-label clinical study to evaluate the safety, efficacy, and pharmacokinetics (PK) of BNT327 at...

Enrolling
Locally Advanced Breast Cancer
Triple Negative Breast Cancer
Drug: BNT327 Dose Level 1 (DL2)
Drug: Antimetabolite

Pegylated arginine deiminase (ADI-PEG 20) will be combined with venetoclax and azacitidine for treatment of subjects with previously treated or untre...

Enrolling
Acute Myeloid Leukemia, Adult
Drug: ADI-PEG 20

The goals of this clinical study are to learn about the safety, tolerability, dosing and effectiveness of magrolimab in combination with nab-paclitax...

Active, not recruiting
Triple-Negative Breast Cancer
Drug: Sacituzumab Govitecan-hziy
Drug: Magrolimab

The goals of this clinical study are to learn about the safety, tolerability, dosing and effectiveness of magrolimab in combination with docetaxel in...

Active, not recruiting
Solid Tumor
Drug: Docetaxel
Drug: Magrolimab

The safety and efficacy of pembrolizumab plus the investigator's choice of chemotherapy will be assessed compared to placebo plus the investigator's...

Active, not recruiting
Breast Neoplasms
Drug: dextrose
Drug: liposomal doxorubicin

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab (MK-3475) plus chemotherapy vs placebo plus chemotherapy as neoadju...

Active, not recruiting
Triple Negative Breast Neoplasms
Biological: Granulocyte colony stimulating factor: Filgrastim or Pegfilgastrim
Drug: Cyclophosphamide

The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) versus placebo in combination with neoadjuvant (pre-surgery...

Active, not recruiting
Breast Cancer
Biological: Pembrolizumab (K)
Radiation: Radiation therapy

Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects with Gastrointestinal, Pancreatic, or Colorectal Cancer

Active, not recruiting
Chemotherapy-induced Thrombocytopenia
Other: Placebo
Biological: Romiplostim

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