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Pacific Cancer Medical Center | Anaheim, CA

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Docetaxel
Gemcitabine
Everolimus
Dexamethasone
Pembrolizumab
Palonosetron
Paclitaxel
Cyclophosphamide
Lenalidomide
Satraplatin

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Active trials

24 of 91 total trials

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer (REZILIENT1)

CLN-081-001 is a Phase 1/2, open label, multi-center study of CLN-081 in patients with non-small cell lung cancer (NSCLC) harboring EGFR (epidermal g...

Enrolling
EGFR Exon 20 Mutation
Non Small Cell Lung Cancer
Drug: CLN-081

This Phase III, randomized, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus everolimus compared with the phy...

Enrolling
Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer
Drug: Fulvestrant
Drug: Dexamethasone Mouth Rinse

The main aim is to evaluate the effect of Ixazomib in combination with lenalidomide and dexamethasone on Multiple Myeloma disease progression at 2 ye...

Active, not recruiting
Multiple Myeloma
Drug: Dexamethasone
Drug: Lenalidomide

The purpose of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL. Participants...

Active, not recruiting
Leukemia, B-cell
Small Lymphocytic Lymphoma
Drug: Pirtobrutinib
Drug: Ibrutinib

This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive...

Enrolling
Colorectal Neoplasms
Drug: levoleucovorin
Drug: leucovorin

This is a Phase I/II, multicenter, open-label study to evaluate the safety, efficacy, tolerability, and pharmacokinetics of a novel BTK inhibitor, Or...

Active, not recruiting
Part 2:B-cell Malignancies
Part 1:r/r B-cell Malignancies
Drug: Orelabrutinib (ICP-022)

This is a Phase 1/2, open-label, multicenter study of HS-10296 with dose escalation, dose expansion and extension cohorts in locally advanced or meta...

Active, not recruiting
Nonsmall Cell Lung Cancer
Drug: HS-10296

This is a Phase I, open-label, multicenter study of HMPL-523 administered orally to patients with relapsed or refractory lymphoma who have exhausted...

Active, not recruiting
Non Hodgkin Lymphoma
Drug: HMPL-523

The phase 3 study is to compare the efficacy and safety of palonosetron, a long-acting 5-HT3 receptor antagonist, by buccal film delivery compared to...

Enrolling
Chemotherapy-induced Nausea and Vomiting
Drug: Palonosetron HCl Buccal Film 0.5 mg
Drug: IV Palonosetron 0.25 mg

Brief Summary:The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFie...

Active, not recruiting
Pancreas Adenocarcinoma
Drug: nab paclitaxel
Drug: Gemcitabine

This trial will evaluate the safety and efficacy of pembrolizumab (MK-3475) in combination with platinum doublet neoadjuvant chemotherapy (NAC) befor...

Active, not recruiting
Non-small Cell Lung Cancer
Drug: Placebo
Drug: Pemetrexed

This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbocic...

Enrolling
Breast Cancer
Drug: Alpelisib
Drug: Fulvestrant

A Phase 1 Dose Escalation and Expanded Cohort Study Of PF-06821497 (Mevrometostat) in Adult Patients With Relapsed/Refractory Small Cell Lung Cancer...

Enrolling
Follicular Lymphoma (FL)
Metastatic Castration Resistant Prostate Cancer (mCRPC)
Drug: Enzalutamide
Drug: Mervometostat (PF-06821497)

The purpose of this study is to compare the effect of Eflapegrastim on duration of neutropenia in patients with early-stage breast cancer when admini...

Active, not recruiting
Breast Cancer
Neutropenia
Biological: Eflapegrastim
Drug: Cyclophosphamide

The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regim...

Active, not recruiting
Head and Neck Cancer
Drug: Pembrolizumab
Drug: Cetuximab

The purpose of this study is to assess the efficacy and safety of platinum-based chemotherapy with or without INCMGA00012 in participants with metast...

Active, not recruiting
Metastatic Nonsquamous Non-Small Cell Lung Cancer
Metastatic Squamous Non-Small Cell Lung Cancer
Drug: Placebo
Drug: Paclitaxel

The purpose of this study is to assess 2 different doses of onvansertib to select the lowest dose that is maximally effective, and to assess the safe...

Enrolling
KRAS/NRAS Mutation
Metastatic Colorectal Cancer
Drug: Bevacizumab
Drug: FOLFOX

The primary objective of this study is to assess the efficacy of 2 different doses of onvansertib in combination with a chemotherapy regimen of irino...

Active, not recruiting
Metastatic Colorectal Cancer
Colorectal Cancer
Drug: Bevacizumab
Drug: Onvansertib

Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects with Gastrointestinal, Pancreatic, or Colorectal Cancer

Active, not recruiting
Chemotherapy-induced Thrombocytopenia
Other: Placebo
Biological: Romiplostim

To evaluate the efficacy of romiplostim for the treatment of CIT in patients receiving chemotherapy for the treatment of NSCLC, ovarian cancer, or br...

Enrolling
Chemotherapy-induced Thrombocytopenia
Drug: Placebo
Drug: Romiplostim

Trial sponsors

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