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Phoenix Children's Hospital | Main - Orthopedics & Sport Injury

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Trials

61 of 255
Status: Active
Trial type: Interventional
Funder type: Industry

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67Cu-SARTATE™ Peptide Receptor Radionuclide Therapy Administered to Pediatric Patients With High-Risk, Relapsed, Refractory Neuroblastoma

The aim of this study is to evaluate the safety and efficacy of 67Cu-SARTATE in pediatric patients with high-risk neuroblastoma.

Enrolling
Refractory Neuroblastoma
Relapsed Neuroblastoma
Drug: 64Cu-SARTATE
Drug: 67Cu-SARTATE

The reason for this 12-month, open-label study is to see if the study drug lasmiditan is safe and effective for the intermittent acute treatment of m...

Enrolling
Migraine
Drug: Lasmiditan

The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common res...

Enrolling
Child
Neoplasms
Drug: Irinotecan
Drug: Ramucirumab

A randomized withdrawal study in which responders to open-label treatment with tofacitinib will be randomized in a 1:1 ratio to tofacitinib or placeb...

Active, not recruiting
Arthritis Juvenile Idiopathic
Drug: In double-blind phase: treatment with tofacitinib or placebo in 1:1 ratio
Drug: In open-label phase: treatment with tofacitinib

This is a Phase I/II, multicenter, open-label, multi-arm study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary effic...

Active, not recruiting
Acute Lymphoblastic Leukemia (ALL)
Neuroblastoma
Drug: Fludarabine
Drug: Idasanutlin

The study's purpose is to see if the drug, abemaciclib, is safe and effective when given with other drugs to kill cancer cells. The study is open to...

Enrolling
Relapsed Solid Tumor
Refractory Solid Tumor
Drug: GM-CSF
Drug: Abemaciclib

This is a Phase 1/2, multicenter, open-label trial of avapritinib in participants 2 to < 18 years of age with advanced relapsed/refractory (R/R) soli...

Enrolling
Solid Tumor, Unspecified, Child
Relapsed Solid Neoplasm
Drug: avapritinib

HOPE-3 is a two cohort, Phase 3, multi-center, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of a ce...

Enrolling
Genetic Diseases, X-Linked
Muscular Diseases
Biological: Placebo
Biological: CAP-1002

This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to plac...

Enrolling
Sickle Cell Disease
Drug: Placebo Tablets
Drug: Etavopivat Tablets High dose

The main purpose of this study is to evaulate the efficacy and safety of galcanezumab in participants 6 to 17 years of age for the preventive treatme...

Enrolling
Episodic Migraine
Drug: Placebo
Drug: Galcanezumab

The purpose of this study is to evaluate the clinical and endoscopic efficacy of guselkumab in pediatric participants with Crohn's Disease (CD) at th...

Enrolling
Crohn's Disease
Drug: Guselkumab
Drug: Placebo

The reason for this study is to see if lasmiditan is safe and effective in children aged 6 to 17 with migraine. The study will last up to 20 weeks an...

Enrolling
Migraine
Drug: Placebo
Drug: Lasmiditan

The main purpose of this study is to measure the effect, safety and how well the body absorbs lebrikizumab in pediatric participants 6 months to <18...

Enrolling
Atopic Dermatitis
Eczema
Drug: Topical corticosteroid
Drug: Placebo

The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to less than (<...

Enrolling
Myasthenia Gravis
Drug: Nipocalimab

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with...

Active, not recruiting
Hypertension, Pulmonary
Drug: Selexipag
Drug: Placebo

The purpose of this study is to determine the safety and tolerability of SNDX-5613 when given in combination with 2 different chemotherapy regimens i...

Active, not recruiting
Acute Lymphocytic Leukemia
Mixed Phenotype Acute Leukemia
Drug: Chemotherapy Regimen 2
Drug: Chemotherapy Regimen 1

This study will assess the efficacy and safety of daily OM-85 treatment compared to placebo in children aged 6 months to 5 years with recurrent wheez...

Enrolling
Wheezing Lower Respiratory Illness
Recurrent Wheezing
Drug: Placebo
Drug: OM-85

The main purpose of this study is to assess the long-term safety and efficacy of lebrikizumab in participants 6 Months to <18 years of age with moder...

Enrolling
Atopic Dermatitis
Eczema
Drug: Lebrikizumab
Drug: Placebo

This Phase 3 study will assess the safety and efficacy of inclacumab, a P-selectin inhibitor, in reducing the frequency of vaso-occlusive crises (VOC...

Active, not recruiting
Vaso-occlusive Crisis
Vaso-occlusive Pain Episode in Sickle Cell Disease
Drug: Placebo
Drug: Inclacumab

ACTIVATE-KidsT (AG348-C-022) is a multicenter study designed to evaluate the efficacy and safety of treatment with mitapivat compared with placebo in...

Active, not recruiting
Pediatric Pyruvate Kinase Deficiency
Pediatric Hemolytic Anemia
Drug: Mitapivat
Drug: Mitapivat-matching placebo

Trial conditions

Leukemia (23 trials)
Precursor Cell Lymphobla... (15 trials)
Syndrome (14 trials)
Neuroblastoma (13 trials)
Acute Myeloid Leukemia (12 trials)
Cystic Fibrosis (10 trials)
Lymphoid Leukemia (10 trials)
Sickle Cell Anemia (10 trials)
Fibrosis (9 trials)
Glioma (9 trials)

And 90 more

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