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QUEST Research Institute | Farmington Hills, MI

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Carbidopa
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Active trials

42 of 101 total trials

A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease (BeyoND)

This is a multi-center, international, open-label, safety study of ND0612, a solution of levodopa/carbidopa (LD/CD) delivered via a pump system as a...

Active, not recruiting
Parkinson's Disease
Drug: ND0612
Locations recently updated

The goal of this Phase 2 clinical trial is to investigate the efficacy and safety of NEU-411 in men and women aged 50-80 years with early Parkinson's...

Enrolling
Idiopathic Parkinson Disease
Early Parkinson Disease (Early PD)
Other: Placebo
Drug: NEU-411

This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and...

Active, not recruiting
Multiple System Atrophy (MSA)
Drug: ONO-2808
Drug: Placebo

The primary objectives of this study are to assess the efficacy of TB006 in improving motor function and to assess the safety of TB006 in participant...

Enrolling
Parkinson's Disease (PD)
Drug: TB006
Drug: Placebo

This is a Phase 2a study to assess the safety and tolerability of TPN-101 patients with PSP.

Active, not recruiting
Progressive Supranuclear Palsy
Drug: Placebo
Drug: TPN-101, 400 mg/day

This is a Phase Ia/Ib, two-part, randomized, placebo-controlled, double-blinded, first in human(FIH) study to evaluate the safety, tolerability, PK,...

Enrolling
Alzheimer Disease
Drug: ADEL-Y01 - healty participants
Drug: ADEL-Y01 - MCI/AD
Locations recently updated

The objective of this randomized, surgically controlled, double-blinded, Phase 2 study is to evaluate the safety and efficacy of AAV2-GDNF delivered...

Enrolling
Parkinson Disease
Procedure: Control Surgery
Drug: AAV2-GDNF Gene therapy

The primary purpose of this study is to evaluate efficacy and safety of CREXONT under real world conditions in participants with Parkinson disease (P...

Enrolling
Parkinson Disease
Drug: CREXONT ER

This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptom...

Active, not recruiting
Alzheimer's Disease
Mental Disorders
Drug: Placebo
Drug: Donanemab

The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease.Additional part...

Active, not recruiting
Alzheimer Disease
Drug: Donanemab
Drug: Placebo

The purpose of this study is to assess the effect of JNJ-64042056 on cognitive decline, as measured by Preclinical Alzheimer's disease Cognitive Comp...

Enrolling
Preclinical Alzheimer's Disease
Drug: JNJ-64042056
Drug: Placebo

The main purpose of this study is to look at how safe the study drug (mevidalen) is and whether it works to alleviate symptoms when given to people w...

Enrolling
Alzheimer Disease
Drug: Placebo
Drug: Mevidalen
Locations recently updated

The goal of this clinical trial is to learn if bezisterim can treat movement symptoms of Parkinson's disease in patients that are 45 to 80 years old,...

Enrolling
Parkinsons Disease (PD)
Drug: Placebo
Drug: NE3107

The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's...

Enrolling
Alzheimer's Disease
Drug: Placebo
Drug: Remternetug

The main aim of this study is to understand how moderate and severe liver impairment (based on the Child-Pugh classification) affects the body's proc...

Enrolling
Hepatic Impairment
Healthy
Drug: Palovarotene

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular injection of different formulations of a hexavalent...

Enrolling
Healthy Volunteers
Influenza
Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1
Biological: Quadrivalent Influenza Vaccine High Dose

Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population. Cli...

Active, not recruiting
Alzheimer's Disease (AD)
Drug: Placebo
Drug: ABBV-916

PROSPER trial is a trial to assess the efficacy of FNP-223 in slowing disease progression in participants with PSP as measured by the PSP Rating Scal...

Enrolling
Progressive Supranuclear Palsy
Drug: FNP-223
Drug: Placebo

The purpose of the study is to assess the safety and efficacy of increasing doses of IPN10200 with the aim to evaluate the Pharmacodynamics (PD) prof...

Active, not recruiting
Spasticity
Biological: Dysport
Biological: IPN10200

The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic...

Enrolling
Chronic Migraine
Other: Placebo
Biological: Botulinum toxin type A

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