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Active trials

15 of 92 total trials

A Study About Modified RNA Vaccines Against Influenza in Healthy Adults

The purpose of this study is to learn if modified RNA (modRNA) vaccines for the prevention of influenza are:* safe; and* how these vaccines produce a...

Active, not recruiting
Influenza, Human
Biological: Influenza ModRNA Vaccine
Biological: Quadrivalent Influenza Vaccine (QIV)
Locations recently updated

The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of MK-2214 in adults with mild cognitive...

Enrolling
Alzheimer Disease
Drug: Placebo
Biological: MK-2214

The purpose of this study is to understand the safety and effects of a combined influenza and COVID-19 vaccine. This combined vaccine is compared to...

Active, not recruiting
COVID-19
Influenza
Biological: COVID-19 Vaccine
Biological: Investigational influenza vaccine

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of different formulations of Quadriva...

Active, not recruiting
Influenza Immunization
Biological: Quadrivalent Influenza mRNA Vaccine MRT5429
Biological: Quadrivalent Influenza mRNA Vaccine MRT5421

The purpose of this study is to learn about the safety and effects of the study vaccine for the possible prevention of influenza. Influenza is a dise...

Enrolling
Grippe
Influenza
Biological: Licensed influenza vaccine
Biological: Placebo

The purpose of this study is to understand how the study medicine (PF-07293893) affects muscle biomarkers. Biomarkers are like clues or signs in our...

Enrolling
Healthy Participants
Drug: PF-07293893
Drug: Placebo

This study is open to adults with overweight or obesity who also have fatty liver disease. The purpose of this study is to find the highest dose of B...

Active, not recruiting
Obesity
Non-alcoholic Fatty Liver Disease
Drug: BI 3006337
Drug: Placebo matching BI 3006337

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential...

Active, not recruiting
Suicidal Ideation
Bipolar Depression
Drug: NRX-101
Drug: Lurasidone HCl

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential...

Active, not recruiting
Suicidal Ideation
Bipolar Depression
Drug: Ketamine Hydrochloride
Drug: Placebo

This is a Phase 3 Randomized Double-Blind Placebo-Controlled 6-month Parallel-Arm Study to Compare a Fixed Dose Combination of AD109 to Placebo in Ob...

Enrolling
OSA
Drug: Placebo
Drug: AD109

The objective of the study is to evaluate the safety, tolerability and immunogenicity of a single injection of VAX-31 at 3 dose levels compared to Pr...

Active, not recruiting
Pneumococcal Vaccines
Biological: 20 valent pneumococcal conjugate vaccine
Biological: 31 valent pneumococcal conjugate vaccine

This Phase 2/3 study is a multi-portion design to confirm that the chosen formulation and dosing regimen of CoVLP has an acceptable immunogenicity an...

Active, not recruiting
SARS-CoV-2 Infection
Biological: Intramuscular vaccine
Drug: Intramuscular injection

Brief Summary of Stage 1:The purpose Stage 1 (Phase I/IIa) is to assess the safety and immunogenicity of a single intramuscular (IM) injection of 3 d...

Active, not recruiting
Respiratory Syncytial Virus Immunization
Biological: RSV vaccine candiate formulation 1
Biological: RSV vaccine candidate formulation 2

The purpose of the Phase 1 Part of this study is to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1403 and mRNA-1405 in healthy adu...

Active, not recruiting
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo
Locations recently updated

An antibody is a substance your body makes to fight off infection. This study will explore the safety and antibody response of a vaccine to prevent s...

Enrolling
Clostridoides Difficile Associated Disease
Biological: C. difficile vaccine formulation 1.
Biological: C. difficile vaccine formulation 3.

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