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KarXT
MET097
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Lemborexant
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Daridorexant
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Active trials

22 of 115 total trials

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" (APPROACH)

The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in part...

Enrolling
Major Depressive Disorder
Behavioral: Psychological Support
Drug: CYB003

This study is designed to test the weight loss effects, safety, and tolerability of multiple monthly doses of MET097 after 12 weekly doses, compared...

Active, not recruiting
Overweight or Obesity
Obesity
Drug: Placebo
Drug: MET097

This study is designed to test how well MET097, an active drug, works to treat individuals with obesity or overweight when compared to placebo. MET09...

Active, not recruiting
Overweight or Obesity
Obesity
Drug: Placebo
Drug: MET097

The purpose of this proof-of-concept trial is to examine the safety, tolerability, and pharmacokinetics (PK), and preliminary clinical efficacy of CY...

Active, not recruiting
Generalized Anxiety Disorder
Behavioral: Psychotherapy
Drug: CYB004

This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmuco...

Enrolling
Treatment Resistant Depression
Drug: VLS-01-BU Placebo
Drug: VLS-01-203 BU

This is a phase 3, open-label extension study to assess the long-term safety of KarXT for the treatment of mania or mania with mixed features in Bipo...

Enrolling
Bipolar Disorder Type I With Mania
Drug: Valproate
Drug: Lamotrigine

The objective of this proof-of-concept study to evaluate mazdutide in participants with alcohol use disorder (AUD).For any individual participant, th...

Active, not recruiting
Alcohol Use Disorder
Drug: Mazdutide
Drug: Placebo

The purpose of this study is to evaluate the dose levels, safety, and drug levels of KarXT intramuscular injection in participants with Schizophrenia

Enrolling
Schizophrenia
Drug: KarXT

The purpose of this study is to evaluate the efficacy and safety of KarXT for the treatment of manic episodes in Bipolar-I Disorder

Enrolling
Bipolar-I Disorder With Mania or Mania With Mixed Features
Drug: KarXT
Other: Placebo

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Active, not recruiting
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

This study is designed to find out how well the COVID-19 vaccine protects people 50 to 64, who don't have any serious health problems, compared to a...

Active, not recruiting
COVID-19
SARS-COV-2 Infection
Biological: Placebo
Biological: BNT162b2 Vaccine

This study evaluates an investigational vaccine designed to protect against Escherichia coli (E coli). The primary objective is to assess the safety...

Enrolling
Healthy Participants
Drug: E coli Vaccine 4 Dose C
Drug: E coli vaccine 3

The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type...

Enrolling
Overweight and/or Obesity
Overweight
Drug: PF-08653944
Other: Placebo

Researchers are looking for new ways to prevent cancers related to human papillomavirus (HPV). HPV is a common virus that can cause an infection. The...

Active, not recruiting
Healthy
Biological: GARDASIL®9
Biological: V540D

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related...

Enrolling
Obesity and Overweight
Drug: Placebo
Drug: MET097

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential...

Active, not recruiting
Suicidal Ideation
Bipolar Depression
Drug: NRX-101
Drug: Lurasidone HCl

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential...

Active, not recruiting
Suicidal Ideation
Bipolar Depression
Drug: Ketamine Hydrochloride
Drug: Placebo

This is a long- term extension of the double-blind trials APPROACH (CYB003-002) and EMBRACE (CYB003-003). Its aim is to examine the safety and long-t...

Invitation-only
Major Depressive Disorder
Drug: CYB003

Researchers are looking for new ways to prevent cancers related to human papillomavirus (HPV). HPV is a common virus that can cause an infection. The...

Active, not recruiting
Healthy
Biological: V540B
Biological: GARDASIL®9 (G9)

This Phase 2/3 study is a multi-portion design to confirm that the chosen formulation and dosing regimen of CoVLP has an acceptable immunogenicity an...

Active, not recruiting
SARS-CoV-2 Infection
Biological: Intramuscular vaccine
Drug: Intramuscular injection

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