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Retina Foundation of the Southwest | Dallas, TX

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QR-421a
VP-001
Zimura
BI 754132
docosahexaenoic acid
VP001
ANX007
QR-1123
Valproic Acid
BI 771716

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Active trials

22 of 70 total trials

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

This is a Phase 1/2 multicenter study with two parallel parts: an observational natural history cohort and an open-label, prospective interventional...

Active, not recruiting
X-Linked Retinitis Pigmentosa
Biological: 4D-125 IVT Injection
Other: Observational

This study will evaluate and compare the safety, efficacy, and tolerability of 2 doses of a recombinant adeno-associated virus vector (AGTC-501/larup...

Enrolling
X-Linked Retinitis Pigmentosa
Drug: Control
Biological: rAAV2tYF-GRK1-hRPGRco

Investigate the Safety, Pharmacokinetics, and Treatment effects of Single and Multi-dose of Intravitreal AVD-104 in participants with geographic atro...

Active, not recruiting
Macular Degeneration
Geographic Atrophy of the Macula
Drug: AVD-104
Drug: Avacincaptad

This Phase 1/2 study will evaluate the safety, tolerability, and preliminary efficacy of subretinal SB-007 administration to determine dose selection...

Enrolling
Stargardt Macular Degeneration
Stargardt Disease
Genetic: SB-007

This is a Phase 3 study to Assess the Efficacy, Safety and Tolerability of OCU400 in patients with retinitis pigmentosa (RP) associated with RHO muta...

Enrolling
Retinitis Pigmentosa
Genetic: Sub-Retinal Administration of OCU400-301

This Phase 2 study is a non-randomized, open-label, study of the safety of AGTC-501 in participants with XLRP who have previously been treated with a...

Invitation-only
X-Linked Retinitis Pigmentosa
Biological: AGTC-501 (high dose and modified corticosteroid regimen)
Biological: AGTC-501 (high dose and standard corticosteroid regimen)

This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retini...

Active, not recruiting
X-Linked Retinitis Pigmentosa
Biological: rAAV2tYF-GRK1-RPGR

The primary purpose of the study is to determine if IVT injections of ANX007 every month reduce vision loss in participants with GA secondary to age-...

Enrolling
Geographic Atrophy
Drug: ANX007
Other: Sham Administration

This is a repeat-dose, open-label, four arm safety and efficacy study of two doses of VP-001 administered intravitreally in participants with confirm...

Begins enrollment in 1 month
Eye Diseases Hereditary
Retinal Degeneration
Drug: VP-001

The purpose of this study is to evaluate change in geographic atrophy (GA) lesion growth of eyes treated with JNJ-81201887 compared to sham control.

Active, not recruiting
Geographic Atrophy
Drug: Triamcinolone
Other: Sham Procedure

This study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in sub...

Active, not recruiting
Eye Diseases, Hereditary
Vision Tunnel
Drug: QR-1123
Other: Sham procedure

This study is open to people 50 years or older with an eye condition called geographic atrophy. The purpose of this study is to compare a medicine ca...

Enrolling
Macular Degeneration, Age-related
Geographic Atrophy
Drug: Pegcetacoplan
Drug: Sham comparator to BI 771716

The purpose of this study is to assess long-term safety of avacincaptad pegol intravitreal administration for patients with geographic atrophy (GA) w...

Active, not recruiting
Age-Related Macular Degeneration
Geographic Atrophy
Drug: avacincaptad pegol

This study will evaluate safety, tolerability, and preliminary efficacy of a single intravitreal (IVT) injection of a recombinant adeno-associated vi...

Active, not recruiting
Choroideremia
Biological: 4D-110

A Phase 1 Open-Label, Multiple Ascending Dose Study to Evaluate the Safety and Tolerability of Intravitreally Administered VP-001 in Participants wit...

Enrolling
Retinal Degeneration
Retinal Dystrophies
Drug: VP-001

A Phase 1 Open-Label, Single Arm Dose Escalation Study to Evaluate the Safety and Tolerability of Intravitreally Administered VP-001 in Participants...

Active, not recruiting
PRPF31 Mutationassociated Retinal Dystrophy
Retinal Dystrophy
Drug: VP-001

This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retini...

Active, not recruiting
X-Linked Retinitis Pigmentosa
Biological: rAAV2tYF-GRK1-RPGR

This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration (AMD)....

Enrolling
Geographic Atrophy
Genetic: OCU410

This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410ST for Stargardt Disease.This is a multicenter study, which will be conducted in...

Enrolling
Stargardt Disease
Genetic: OCU410ST

This study is an open-label, single ascending dose clinical trial in participants who have ABCA4-related retinopathies. This is the first-in-human cl...

Enrolling
Cone Rod Dystrophy
Stargardt Disease
Drug: ACDN-01

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