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Rhode Island Hospital | Brown Dermatology Research - Clinical Trials Unit

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Active trials

15 of 96 total trials

A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors

This is a Phase 1 study to assess the safety and clinical activity of RO7623066 alone and in combination in patients with advanced solid tumors.

Enrolling
Advanced Solid Tumors
Drug: RO7623066
Drug: Olaparib

This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulati...

Enrolling
Colorectal Cancer Stage III
Colorectal Cancer Stage II
Drug: RO7198457 intravenous (IV)
Other: Observational group (no intervention)

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cance...

Enrolling
Breast Neoplasms
Drug: Anastrozole
Drug: Tamoxifen

The purpose of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL. Participants...

Active, not recruiting
Leukemia, B-cell
Small Lymphocytic Lymphoma
Drug: Pirtobrutinib
Drug: Ibrutinib

Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population. Cli...

Active, not recruiting
Alzheimer's Disease (AD)
Drug: Placebo
Drug: ABBV-916

The objective of this study is to assess the efficacy and safety of upadacitinib combined with topical corticosteroids (TCS) for the treatment of ado...

Invitation-only
Atopic Dermatitis
Drug: Placebo
Drug: Upadacitinib

The study (dose escalation/expansion) is being conducted to assess the safety and tolerability of SHR-A1904 in subjects with advanced solid tumors, a...

Enrolling
Advanced Solid Tumors
Drug: SHR-A1904

The purpose of the study is to assess the safety and effectiveness of the GORE® EXCLUDER® Conformable AAA Endoprosthesis to treat an infrarenal aneur...

Active, not recruiting
Aortic Aneurysm, Abdominal
Device: GORE® EXCLUDER® Conformable AAA Endoprosthesis

Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Rest...

Enrolling
Dilated Cardiomyopathy
Heart Failure With Reduced Ejection Fraction (HFrEF)
Device: AccuCinch Ventricular Restoration System
Drug: Guideline-Directed Medical Therapy

The purpose of this clinical trial is to assess and evaluate the safety and efficacy of the Treovance Stent-Graft with Navitel Delivery System in sub...

Active, not recruiting
Abdominal Aortic Aneurysm (AAA)
Device: Subjects who receive the Treovance stent-graft

LIN-MD-66 is a Phase 3 open-label study with 24 weeks (Functional Constipation participants) or 52 weeks (Irritable bowel syndrome with constipation...

Active, not recruiting
Functional Constipation
Irritable Bowel Syndrome With Constipation
Drug: Functional Constipation (FC) participants (LIN-MD-62 and LIN-MD-64 completers)
Drug: Irritable Bowel Syndrome with Constipation (IBS-C) participants (LIN-MD-63 completers)

A randomized Phase II clinical trial will be conducted to assess the impact on progression free survival (PFS) with the addition of ixazomib and dara...

Active, not recruiting
Myeloma, Multiple
Drug: Ixazomib
Drug: Daratumumab Injection

This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent gliomas, circumscribed a...

Active, not recruiting
Glioblastoma
Adult-type Diffuse Gliomas
Drug: Pemigatinib

The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in H...

Active, not recruiting
Aortic Valve Stenosis
Biological: Optimal Heart Failure Therapy
Device: SAPIEN 3 THV
Locations recently updated

This study will evaluate the safety, pharmacokinetics, and preliminary efficacy of mosunetuzumab following first-line diffuse large B-cell lymphoma (...

Active, not recruiting
Diffuse Large B-cell Lymphoma
Drug: Polatuzumab Vedotin
Drug: Mosunetuzumab Intravenous (IV)

Trial sponsors

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Beth Israel Lahey Health logo

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