Rhode Island Hospital | Brown Dermatology Research - Clinical Trials Unit

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593 Eddy Street Jane Brown South Room 115, Providence, Rhode Island, United States of America
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98 of 832
Status: Active
Trial type: Interventional
Funder type: Industry

9-ING-41 in Patients With Advanced Cancers

GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and e...

Active, not recruiting
Neoplasm of Lung
Neoplasms Pancreatic
Drug: Gemcitabine - 21 day cycle
Drug: Lomustine

This is a phase 2 study designed to assess the safety, tolerability and efficacy of NLY01 in subjects with early untreated Parkinson's disease (PD)....

Active, not recruiting
Parkinson Disease
Drug: NLY01
Drug: Vehicle

AGENT IDE is a Prospective, Randomized (2:1), Multicenter Trial. The purpose of this study is to assess the safety and effectiveness of the Agent Pac...

Active, not recruiting
In-Stent Restenosis
Device: PTCA balloon catheter

Phase I, open-label, multi-center study

Locally Advanced or Metastatic Solid Tumors
Drug: SPYK04

The main goals of this study are to further determine whether the study drug donanemab is safe and effective in participants with Alzheimer's disease...

Active, not recruiting
Alzheimer Disease
Cognitive Impairment
Other: No Intervention
Drug: donanemab

A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients with Relapsed/Refracto...

AML, Adult Recurrent
Drug: Decitabine
Drug: LYT-200

The purpose of this study is to assess progression-free survival (PFS) and overall survival (OS) in newly diagnosed Glioblastoma (GBM) participants t...

Drug: SOC: Temozolomide
Combination Product: Placebo

This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulati...

Colorectal Cancer Stage III
Colorectal Cancer Stage II
Other: Observational group (no intervention)
Drug: RO7198457 intravenous (i.v.)

Study GO43104 is a Phase III, randomized, open-label, multicenter study of lurbinectedin in combination with atezolizumab compared with atezolizumab...

Active, not recruiting
Small-Cell Lung Cancer
Drug: Etoposide
Drug: Atezolizumab

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche...

Active, not recruiting
Multiple Sclerosis
Drug: Ocrelizumab

This is a single-arm, open-label study to assess the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of tocilizumab (TCZ) for th...

Drug: Tocilizumab

This phase II trial studies the side effects and how well nirogacestat works in treating patients less than 18 years of age with desmoid tumors that...

Active, not recruiting
Desmoid Fibromatosis
Unresectable Desmoid Fibromatosis
Procedure: Magnetic Resonance Imaging
Other: Quality-of-Life Assessment

The purpose of this study is to determine the safety, tolerability, and maximal tolerated dose (MTD) of the combination of Abemaciclib and Sunitinib...

Active, not recruiting
Renal Cell Carcinoma Metastatic
Drug: Sunitinib
Drug: Abemaciclib

ASP2074 is a potential new treatment for people with certain solid tumors. Before ASP2074 is available as a treatment, the researchers need to unders...

Advanced Solid Tumors
Drug: ASP2074

The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and...

Solid Tumors
Drug: Nivolumab
Drug: DF6002

A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Pati...

Active, not recruiting
Gastric Cancer
GastroEsophageal Cancer
Drug: Capecitabine 1000mg/ m2 BID
Drug: DKN-01 600mg

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cance...

Breast Neoplasms
Drug: Letrozole
Drug: Tamoxifen

The reason for this study is to see if the study drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in part...

Active, not recruiting
Endometrial Cancer
Breast Cancer
Drug: Trastuzumab
Drug: Everolimus

The main aim is to see how the combination of pevonedistat + venetoclax + azacitidine compares to venetoclax + azacitidine in adults recently diagnos...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Drug: Venetoclax
Drug: Pevonedistat

The purpose of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL. Participants...

Leukemia, B-cell
Small Lymphocytic Lymphoma
Drug: Pirtobrutinib
Drug: Ibrutinib

Trial conditions

Leukemia (62 trials)
Cancer (53 trials)
Lymphoma (49 trials)
Breast Cancer (41 trials)
Lung Cancer (40 trials)
Carcinoma (32 trials)
Precursor Cell Lymphobla... (32 trials)
Alzheimer Disease (31 trials)
Lymphoid Leukemia (30 trials)
Non-Small-Cell Lung Carc... (26 trials)

And 90 more

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