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Active trials

20 of 132 total trials

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.

Enrolling
Ischemic Stroke; Ischemic Attack, Transient
Drug: Placebo
Drug: Milvexian

The purpose of this study is to compare event-free survival (EFS) in participants with Bacillus Calmette-Guerin (BCG)-naive high-risk non-muscle inva...

Active, not recruiting
Bladder Cancer
Biological: Cetrelimab
Drug: TAR-200

The purpose of this study is to demonstrate safety and effectiveness of the Biosense Webster (BWI) ablation system (THERMOCOOL SMARTTOUCH surround fl...

Active, not recruiting
Drug Refractory Paroxysmal Atrial Fibrillation
Device: THERMOCOOL STSF Bi- Directional Navigation Catheter
Device: TRUPULSE Generator

This is a Phase 2 study to evaluate the clinical activity and safety of ZN-c3 (azenosertib) in adult women with recurrent or persistent uterine serou...

Enrolling
Uterine Serous Carcinoma
Drug: ZN-c3

The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valv...

Enrolling
Atrial Fibrillation
Stroke
Drug: Non-Vitamin K Oral Antagonists
Device: Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder)

The purpose of this study is to establish the safety and effectiveness of the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device, including the po...

Active, not recruiting
Stroke
Device: WATCHMAN LAAC Device Implant
Drug: Single Antiplatelet Therapy or No Therapy (Control)

Prospective, non-randomized, multi-center, international study designed to evaluate the safety and effectiveness of the Aveir™ Dual-Chamber (DR) Lead...

Active, not recruiting
Bradycardia
Cardiac Rhythm Disorder
Device: Aveir DR Leadless Pacemaker System

A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval m...

Enrolling
Hypertension
Hypertension, Essential
Device: Medtronic Astra/Azure DR MRI IPG with AVIM therapy Deactivated
Device: Medtronic Astra/Azure DR MRI IPG with AVIM therapy Activated

The purpose of the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgi...

Active, not recruiting
Mitral Valve Regurgitation
Mitral Regurgitation
Device: MitraClip System

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maint...

Enrolling
Venous Thromboembolism
Deep Venous Thrombosis
Device: ClotTriever System
Drug: Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.

The purpose of this trial is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft Systems verses Gore Exc...

Enrolling
Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder)
Abdominal Aortic Aneurysm
Device: Gore Excluder or Gore/ Excluder Conformable AAA Endoprosthesis
Device: Medtronic Endurant II or Endurant IIs Stent Graft System

This study will monitor the safety and valve performance of the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with symptomatic,...

Active, not recruiting
Aortic Valve Stenosis
Device: TAVR with CENTERA THV

Inappropriate Sinus Tachycardia (IST) is a prevalent and debilitating condition in otherwise healthy younger patients, resulting in significant loss...

Enrolling
Inappropriate Sinus Tachycardia
Device: AtriCure ISOLATOR Synergy Surgical Ablation System

The primary objective of this study is to collect real-world data on WATCHMAN FLX™ Pro Left Atrial Appendage Closure (LAAC) Device in patients with n...

Active, not recruiting
Atrial Fibrillation
Stroke
Device: WATCHMAN FLX Pro LAAC Device

This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effec...

Enrolling
Ischemic Stroke
Systemic Embolism
Device: AtriClip LAA Exclusion System

The primary objective of this study is to collect sensor data from insertable cardiac monitor systems.

Active, not recruiting
Heart Failure
Device: Investigational LUX-Dx ICM Implant
Recently updated

The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with...

Enrolling
Persistent Atrial Fibrillation
Device: FARAPULSE™ Pulsed Field Ablation (PFA) System
Drug: Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone

Multicenter, Prospective, Randomized Controlled, Blinded Trial, with a Non-implant Control group; 1:1 randomization.

Active, not recruiting
Heart Failure
Other: intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Device: IASD System II implant

Chronic Obstructive Pulmonary Disease (COPD) is defined as an impaired ability to move air within the lungs and is a major public health problem that...

Active, not recruiting
Chronic Bronchitis
Device: Sham Control Procedure
Device: RejuvenAir System

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) fo...

Enrolling
Mitral Valve Insufficiency
Mitral Regurgitation
Device: SAPIEN M3 valve and dock

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