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Mitapivat
AG-348
Osivelotor
Crizanlizumab
Concizumab
Anumigilimab
Crovalimab
Rilzabrutinib
CSL324

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Active trials

6 of 8 total trials

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.

Enrolling
Sickle Cell Disease
Drug: Osivelotor

This clinical trial is a Phase 2/3 study that will determine the recommended dose of mitapivat and evaluate the efficacy and safety of mitapivat in s...

Active, not recruiting
Sickle Cell Disease
Other: Mitapivat-matching placebo
Drug: Mitapivat

The primary objective of this study is to determine the effect of mitapivat versus placebo on the need for transfusions in subjects with SCD.

Enrolling
Sickle Cell Disease
Drug: Mitapivat
Drug: Mitapivat Matched Placebo

A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo...

Enrolling
Sickle Cell Disease
Biological: Crizanlizumab
Drug: Placebo

This is a phase 2a, global, multicenter, randomized, double-blind, placebo-controlled study investigating the safety of anumigilimab administered sub...

Enrolling
Sickle Cell Disease
Biological: Anumigilimab
Drug: Placebo

This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, flexible-adaptive, group-sequential study (Part A), followed by...

Enrolling
Sickle Cell Disease
Drug: Rilzabrutinib
Drug: Placebo

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