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Active trials

30 of 82 total trials

A Phase 1 Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis

ABBV-CLS-7262 is an investigational drug being researched for the treatment of Amyotrophic Lateral Sclerosis. This is an up to 156-week, 2-part study...

Active, not recruiting
ALS
Amyotrophic Lateral Sclerosis
Drug: Placebo
Drug: ABBV-CLS-7262

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse....

Active, not recruiting
Cytochrome P-450
Antineoplastic Agents, Hormonal
Drug: Placebo for Abemaciclib
Drug: Abemaciclib

This is a global Phase III, randomized, placebo-controlled, double-blind study designed to evaluate the efficacy and safety of adjuvant treatment wit...

Enrolling
Muscle-invasive Bladder Cancer
Drug: Atezolizumab
Other: Placebo

The primary objective of the study is to demonstrate superior efficacy of Xevinapant (Debio 1143) vs placebo when added to chemoradiotherapy (CRT) in...

Active, not recruiting
Squamous Cell Carcinoma of the Head and Neck
Drug: Placebo
Drug: Xevinapant (Debio 1143)

This is a multicenter, Phase 2a, open-label, 2-part study to investigate the safety, tolerability, and anti-tumor activity of ZW25 (zanidatamab) in c...

Active, not recruiting
HER2+/HR+ Breast Cancer
Drug: ZW25 (Zanidatamab)
Drug: Palbociclib

A study to learn about a new medicine called ARV-471 (PF-07850327) in people who have advanced metastatic breast cancer.

Enrolling
Advanced Breast Cancer
Drug: Fulvestrant
Drug: ARV-471

The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) administered as a single agent and in combi...

Enrolling
Glioma
Melanoma
Drug: PF-07799544
Drug: encorafenib

The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm...

Enrolling
Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Drug: Venetoclax
Drug: Rituximab

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called cemipli...

Enrolling
Melanoma
Drug: Pembrolizumab
Drug: Fianlimab

The goal of this clinical trial is to test alternative dosing of niraparib in patients with newly diagnosed high-grade, advanced stage ovarian cancer...

Enrolling
Stage III Ovarian Cancer
High Grade Ovarian Serous Adenocarcinoma
Drug: Niraparib

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 in...

Enrolling
Brain Tumor
Device: Exablate
Drug: Doxorubicin

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for...

Enrolling
Brain Tumor
Device: Blood Brain Barrier Disruption - Oncology
Drug: Pembrolizumab

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for...

Enrolling
Glioblastoma
Glioma
Device: Focused Ultrasound (Exablate Model 4000)

Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the k...

Enrolling
Knee Injuries
Cartilage Injury
Device: Microfracture plus placement of Chondro-Gide® ACC
Procedure: Microfracture

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called REGN281...

Enrolling
Melanoma
Drug: Cemiplimab
Drug: Placebo

The purpose of this study is to determine if enzalutamide given in combination with exemestane is safe and effective in patients with advanced breast...

Active, not recruiting
Breast Cancer
Drug: Enzalutamide
Drug: exemestane

A Phase 2b/3 multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety and tolerability of MN-...

Enrolling
Amyotrophic Lateral Sclerosis
Drug: placebo
Drug: MN-166

To determine whether Instylla HES has the ability to effectively embolize targeted arterial segments of hypervascular tumors as well as (i.e., is non...

Active, not recruiting
Hypervascular Tumors
Other: TAE or cTACE
Device: Instylla HES

This phase II single-armed study will examine the clinical utility of retreating patients with osimertinib, in the third-line, following first-line t...

Enrolling
Non-Small Cell Lung Cancer
Drug: Platinum + Pemetrexed Chemotherapy Second-Line
Drug: Osimertinib First-Line

A Phase I-II, First-in-Human Study of SKB264 in Patients with Locally Advanced Unresectable/Metastatic Solid Tumors who are refractory to Available S...

Enrolling
Endometrial Carcinoma
Breast Cancer
Drug: SKB264

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