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Active trials

14 of 30 total trials

A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (OCEANIC-STROKE)

Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the...

Enrolling
High-risk Transient Ischemic Attack
Acute Non-cardioembolic Ischemic Stroke
Drug: Asundexian (BAY2433334)
Drug: Placebo
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To determine the safety and effectiveness of IMPEDE-FX RapidFill to increase the percentage of subjects with shrinkage of the abdominal aortic aneury...

Enrolling
Aortic Aneurysm, Abdominal
Procedure: EndoVascular Aneurysm Repair
Device: IMPEDE-FX RapidFill Implants

The Amulet™ device will be evaluated for safety and efficacy by demonstrating its performance is non-inferior to the commercially available WATCHMAN®...

Active, not recruiting
Stroke
Device: WATCHMAN Left Atrial Appendage Closure
Device: Amulet Left Atrial Appendage Occluder

The purpose of this study is to establish the safety and effectiveness of the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device, including the po...

Active, not recruiting
Stroke
Device: WATCHMAN LAAC Device Implant
Drug: Single Antiplatelet Therapy or No Therapy (Control)

The purpose of this study is to assess the safety and performance of the Caisson Interventional Transcatheter MitralValve Replacement (TMVR) system f...

Active, not recruiting
Mitral Valve Regurgitation
Device: Caisson TMVR System

Prospective, controlled, multicenter clinical investigation with four trial cohorts: Randomized, Non-repairable, Severe Mitral Annular Calcification...

Enrolling
Heart Valve Diseases
Degenerative Mitral Valve Disease
Device: Tendyne Mitral Valve System
Device: MitraClip System

The PERFORMANCE III study is a prospective, multicenter single-arm, open label study to evaluate the safety and effectiveness of the Neuroguard IEP®...

Enrolling
Carotid Stenosis
Carotid Artery Diseases
Device: Neuroguard IEP Direct System

Evaluate the Safety and Effectiveness of Staged Bilateral Exablate Ablation of the Pallidothalamic Tract (PTT) for the Treatment of the Motor Complic...

Active, not recruiting
Parkinson Disease
Device: Exablate 4000

The purpose of this study is to evaluate the safety and performance of the Tendyne Mitral Valve System in the treatment of severe mitral regurgitatio...

Active, not recruiting
Mitral Valve Regurgitation
Device: Tendyne Mitral Valve System

The study objective is to demonstrate that the safety and effectiveness of the Medtronic TAVR system as measured by rates of all-cause mortality or d...

Active, not recruiting
Aortic Valve Stenosis
Device: Surgical Aortic Valve Replacement (SAVR)
Device: Medtronic Transcatheter Aortic Valve Replacement Systems

The objective of the PORTICO pivotal IDE trial is to evaluate the safety and effectiveness of the St Jude Medical (SJM) Portico Transcatheter Heart V...

Enrolling
Aortic Valve Stenosis
Device: Commercially available transcatheter aortic valve
Device: Portico transcatheter aortic valve

The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptom...

Active, not recruiting
Severe Aortic Stenosis
Procedure: Surgical Aortic Valve Replacement (SAVR)
Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) fo...

Enrolling
Mitral Valve Insufficiency
Mitral Regurgitation
Device: SAPIEN M3 valve and dock

The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomati...

Active, not recruiting
Tricuspid Regurgitation
Device: TriClipTM Device

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