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The University of Sydney | Sydney Eye Hospital

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Top treatments

Faricimab
Dexamethasone
KHK4951
Ranibizumab
RHPRG4
KIO-104
Zimura
Presendin
AZR-MD-001
VRDN 001

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Active trials

19 of 41 total trials

A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP

This study will evaluate and compare the safety, efficacy, and tolerability of 2 doses of a recombinant adeno-associated virus vector (AGTC-501/larup...

Active, not recruiting
X-Linked Retinitis Pigmentosa
Drug: Control
Biological: rAAV2tYF-GRK1-hRPGRco

rhPRG4-Sjögren's-002 is a prospective multi-center study conducted in Australia to evaluate the safety and efficacy of topically-applied rhPRG4 in su...

Not yet enrolling
Sjögren's Syndrome
Drug: Vehicle Control
Drug: Recombinant Human Proteoglycan 4

An 84-day, prospective, randomized (1:1) vehicle controlled, double-masked pre-market, crossover study. Subjects with moderate to severe oGVHD relate...

Not yet enrolling
Ocular Graft Versus Host Disease
Drug: rhPRG4 450ug/ml
Drug: Vehicle Control

The investigational drug, VRDN-001, is a monoclonal antibody that inhibits the activity of a cell surface receptor called insulin-like growth factor-...

Active, not recruiting
Thyroid Eye Disease
Drug: VRDN-001 10 mg/kg
Drug: VRDN-001 3 mg/kg

The primary purpose of the study is to determine if IVT injections of ANX007 every month reduce vision loss in participants with GA secondary to age-...

Enrolling
Geographic Atrophy
Drug: ANX007
Other: Sham Administration

This study aims to evaluate the efficacy, safety and tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of efgartigimod P...

Enrolling
Thyroid Eye Disease
Other: Placebo PH20 SC
Combination Product: Efgartigimod PH20 SC
Status recently updated

Study WR42221 is a Phase IIIb, global, multicenter, randomized, visual assessor-masked study designed to assess the efficacy, safety, and pharmacokin...

Enrolling
Active, not recruiting
Neovascular Age-related Macular Degeneration (nAMD)
Device: Port Delivery System with Ranibizumab
Drug: Ranibizumab

This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of int...

Enrolling
Neovascular Age-related Macular Degeneration (nAMD)
Drug: Faricimab

This is a Phase III, multicenter, randomized, double-masked, active comparator-controlled study evaluating the efficacy and safety of faricimab in pa...

Active, not recruiting
Choroidal Neovascularization Secondary to Pathologic Myopia
Procedure: Sham Procedure
Drug: Faricimab

The goal of this clinical trial is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of VX-01 as stand-alone treatmen...

Enrolling
NPDR - Non Proliferative Diabetic Retinopathy
Diabetic Retinopathy
Drug: VX-01
Drug: Placebo

The purpose of this study is to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of subcutaneous (SC) satralizumab, a recombinant,...

Active, not recruiting
TED
Thyroid Eye Disease
Drug: Satralizumab
Drug: Placebo

The study consists of a randomized double-masked, placebo-controlled, parallel-group, multicenter trial with an optional open-label treatment period...

Active, not recruiting
Thyroid Eye Disease
Other: Placebo
Biological: Teprotumumab

This study will be a randomized, vehicle-controlled, double-masked, multiple-dose, parallel-group study to evaluate the efficacy, safety and tolerabi...

Enrolling
Dry Eye
Drug: BTV100 High dose
Drug: BTV100 Low dose

The purpose of this global, multicenter, open-label, Phase 4 clinical extension study is to evaluate the long-term safety and efficacy of revakinagen...

Not yet enrolling
Macular Telangiectasia Type 2 (MacTel)
Combination Product: NT-501/revakinagene taroretcel-lwey

This is a multi-center, open label study to assess the safety, tolerability, and efficacy of KIO-104 administered by IVT injection to the study eye o...

Enrolling
Macular Edema
Drug: KIO-104

The purpose of this study is to evaluate efficacy and safety of KHK4951 eye drops in patients with DME.

Enrolling
Diabetic Macular Edema (DME)
Drug: KHK4951
Drug: Aflibercept Injection

The purpose of this study is to evaluate efficacy and safety of KHK4951 eye drops in patients with nAMD.

Enrolling
Neovascular Age-Related Macular Degeneration (nAMD)
Drug: Aflibercept Injection
Drug: KHK4951

This study will assess the efficacy and safety of vamikibart in participants with uveitic macular edema.

Active, not recruiting
Uveitic Macular Edema
Other: Sham
Drug: Vamikibart

The VividWhite Glaucoma Implant (VW-51) is a novel surgical implant designed to treat glaucoma. This study is a 12-month, 65-participant non-comparat...

Enrolling
Glaucoma
Device: VividWhite Glaucoma Implant (VW-51)

Trial sponsors

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