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Universitätsklinikum Essen | Innere Klinik(Tumorforschung) - Westdeutsches Tumorzentrum

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Active trials

55 of 267 total trials

"InDACtion" vs "3+7" Induction in AML

Older patients with acute myeloid leukemia (AML) have a small (\< 10%) chance of long-term survival. Despite the treatment of elderly AML patients wi...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Drug: decitabine
Drug: standard combination chemotherapy

This trial is an extension of the antecedent trial ARGX-117-2002. It is a multicenter trial that has been designed to evaluate the long-term safety a...

Invitation-only
Multifocal Motor Neuropathy (MMN)
Other: Placebo
Biological: ARGX-117

This open-label, single-arm study will evaluate the safety and expression of delandistrogene moxeparvovec in participants with DMD. Participants will...

Enrolling
Duchenne Muscular Dystrophy
Genetic: delandistrogene moxeparvovec

Evaluate the safety and tolerability of sotorasib in adult subjects with KRAS p.G12C mutant advanced solid tumors.Estimate the maximum tolerated dose...

Active, not recruiting
KRAS p.G12C Mutant Advanced Solid Tumors
Drug: sotorasib
Drug: Anti PD-1/L1

The goal of this clinical trial is to identify the optimal dose of RMC-035 for protection of long-term renal function in adult patients undergoing ca...

Begins enrollment this month
Kidney Injury Following Open-Chest Cardiac Surgery
Drug: Placebo
Drug: RMC-035

The primary objective of this study is:• To evaluate the long-term safety of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia...

Invitation-only
Warm Antibody Autoimmune Hemolytic Anemia
Drug: Fostamatinib disodium

This study aims to examine the efficacy and safety of obexelimab for the prevention of flare of IgG4-related disease (IgG4-RD)

Enrolling
IgG4 Related Disease
Drug: Obexelimab
Other: Placebo

The Alternative-C Trial is a prospective, multicenter Phase 2 Study to evaluate the efficacy of the chemotherapy-free combination of copanlisib and o...

Active, not recruiting
Follicular Lymphoma
Drug: Obinutuzumab
Drug: Copanlisib

This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plu...

Active, not recruiting
Diffuse Large B-Cell Lymphoma
Drug: Vincristine Placebo
Drug: Polatuzumab vedotin Placebo

This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with end...

Enrolling
Early Breast Cancer
Drug: Endocrine Therapy of Physician's Choice
Drug: Abemaciclib
Recently updated

This clinical trial is a Phase 2/3 study that will determine the recommended dose of mitapivat and evaluate the efficacy and safety of mitapivat in s...

Enrolling
Sickle Cell Disease
Other: Mitapivat-matching placebo
Drug: Mitapivat
Recently updated

The primary purpose of this study is to compare the effect of mitapivat versus placebo on anemia in participants with alpha- or beta-non-transfusion...

Active, not recruiting
Non-Transfusion-dependent Alpha-Thalassemia
Non-Transfusion-dependent Beta-Thalassemia
Drug: Placebo Matching Mitapivat
Drug: Mitapivat
Recently updated

The primary purpose of this study is to compare the effect of mitapivat versus placebo on transfusion burden in participants with transfusion-depende...

Active, not recruiting
Transfusion-dependent Alpha-Thalassemia
Transfusion-dependent Beta-Thalassemia
Drug: Placebo Matching Mitapivat
Drug: Mitapivat

This is an umbrella study evaluating the efficacy and safety of multiple treatment combinations in participants with metastatic or inoperable locally...

Enrolling
Breast Cancer
Drug: Abemaciclib
Drug: Ribociclib

Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat...

Enrolling
Migraine
Medication Overuse Headache
Drug: Placebo
Drug: Eptinezumab

This study will be comprised of 2 parts: Part 1 (dose escalation) will be conducted to evaluate the safety and tolerability of 2 doses (100 milligram...

Active, not recruiting
Muscular Dystrophy, Duchenne
Drug: Eteplirsen

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria,...

Enrolling
Chronic Kidney Disease
Proteinuria
Drug: Finerenone (Kerendia, BAY94-8862)

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria,...

Enrolling
Chronic Kidney Disease
Proteinuria
Drug: Finerenone (Kerendia, BAY94-8862)
Drug: Placebo

This prospective, randomized, multicenter, open-label Phase 2 study is designed to evaluate the superiority of InO monotherapy vs ALLR3 after 1 cycle...

Enrolling
ACUTE LYMPHOBLASTIC LEUKEMIA
Drug: Inotuzumab ozogamicin
Drug: ALLR3

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a p...

Active, not recruiting
Solid Tumors Harboring NTRK Fusion
Drug: BAY2757556 (Larotrectinib, Vitrakvi)

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