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Active trials

34 of 300 total trials

64Cu-SAR-bisPSMA Positron Emission Tomography: A Phase 3 Study of Participants With Biochemical Recurrence of Prostate Cancer (AMPLIFY)

The aim for this study is to investigate the ability of 64Cu-SAR-bisPSMA PET/CT to detect recurrence of prostate cancer

Enrolling
Prostate Cancer Patients Who Have Brachytherapy Seed Implant
Prostate Cancer Patients Treated by Radiotherapy
Drug: 64Cu-SAR-bisPSMA

This is a multi-center, international, open-label, safety study of ND0612, a solution of levodopa/carbidopa (LD/CD) delivered via a pump system as a...

Active, not recruiting
Parkinson's Disease
Drug: ND0612

The purpose of this Phase 2 Study is to see if the investigational study drug, laruparetigene zovaparvovec, also known as AGTC-501, given in both eye...

Enrolling
X-Linked Retinitis Pigmentosa (XLRP)
Biological: Adeno-associated virus vector expressing a human RPGR gene

EFC18419 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the...

Enrolling
Chronic Rhinosinusitis With Nasal Polyps
Drug: Mometasone furoate nasal spray (MFNS)
Drug: Itepekimab (SAR440340)

This is a Phase 1/2 repeat-dose, open-label, two-arm, parallel group safety and efficacy study of two doses of VP-001 (30 μg and 75 μg) in participan...

Enrolling
Eye Diseases Hereditary
Retinal Degeneration
Drug: VP-001
Locations recently updated

The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than...

Enrolling
Carcinoma, Non-Small-Cell Lung
Neoplasm Metastasis
Drug: Carboplatin
Drug: Pemetrexed

The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegaloviru...

Active, not recruiting
Cytomegalovirus
Biological: mRNA-1647
Other: Placebo

The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravi...

Enrolling
Myasthenia Gravis
Drug: Nipocalimab SC-LIV
Drug: Nipocalimab

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus predniso...

Active, not recruiting
Metastatic Castration-sensitive Prostate Cancer
Drug: Niraparib
Drug: Prednisone

The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate plus prednisone (AAP) compared to AAP...

Active, not recruiting
Castration-Resistant Prostatic Cancer
Drug: Prednisone
Drug: New Formulation of Niraparib and Abiraterone Acetate (AA)

The main aim of the study is to check effectiveness, side effects, and tolerability of vonicog alfa (recombinant von Willebrand factor \[rVWF\]), wit...

Enrolling
Von Willebrand Disease
Biological: Antihemophilic Factor (Recombinant)
Biological: Vonicog alfa

The purpose of this study is to evaluate the anti-tumor effects of TAR-200 in combination with intravenous (IV) cetrelimab and IV cetrelimab alone.

Active, not recruiting
Urinary Bladder Neoplasms
Biological: Cetrelimab
Drug: TAR-200

The main purpose of the proposed study is to evaluate the efficacy of efgartigimod PH20 SC in patients with moderate-to-severe Primary Sjögren's Dise...

Active, not recruiting
Primary Sjogrens Disease
Biological: Efgartigimod PH20 SC
Other: Placebo PH20 SC

The main purpose of this study is to measure how well adults with new-onset gMG (which means they've had generalized disease signs and/or symptoms fo...

Enrolling
New Onset Generalized Myasthenia Gravis (gMG)
Biological: Efgartigimod PH20 SC

The XEN1101 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and toler...

Active, not recruiting
Focal Epilepsy
Drug: XEN1101

This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left...

Enrolling
Heart Failure
Drug: empagliflozin
Drug: placebo

This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the...

Enrolling
Open-angle Glaucoma
Ocular Hypertension
Other: Sham Administration
Drug: AGN-193408 SR

This study is open to adults aged 18 years and older with bronchiectasis. People can join the study if they were previously enrolled in another study...

Active, not recruiting
Bronchiectasis
Drug: Placebo matching BI 1291583
Drug: BI 1291583

The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards Transcatheter Atrial Shunt Sy...

Active, not recruiting
Heart Failure
Device: Transcatheter Atrial Shunt System

This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 y...

Enrolling
Diabetic Retinopathy
Other: Placebo
Drug: Fenofibrate

Trial sponsors

National Institute of Allergy and Infectious Diseases (NIAID) logo
Boehringer Ingelheim logo
Jaeb Center for Health Research logo
University of Florida logo
Duke University logo
United Therapeutics logo
Janssen (J&J Innovative Medicine) logo
National Cancer Institute (NCI) logo
Eisai logo
Sanofi logo

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