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University of Kentucky | Kentucky Clinic, Kentucky Neuroscience Institute

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Active trials

33 of 313 total trials

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )

This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3

Enrolling
NASH - Nonalcoholic Steatohepatitis
Drug: Placebo
Drug: IVA337

The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in pa...

Active, not recruiting
Cystic Fibrosis
Drug: VX-121/TEZ/D-IVA

The purpose of this study is to compare the efficacy of Bortezomib, Lenalidomide and Dexamethasone (VRd) induction followed by a single administratio...

Active, not recruiting
Multiple Myeloma
Drug: Lenalidomide
Drug: Bortezomib

The aim of this study is to assess the safety, side effects and effectiveness of EP0031 in patients with advanced RET-altered malignancies

Enrolling
Advanced Solid Tumor
Drug: EP0031

The goal of this multicenter study is to test JNJ-90009530 in Relapsed or Refractory Non-Hodgkin Lymphoma Patients. The main questions the study aims...

Enrolling
Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Drug: JNJ-90009530

The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel (administered once following lymphodepletion) versus Stan...

Enrolling
Lupus Erythematosus, Systemic
Lupus Nephritis
Other: Standard of Care
Biological: rapcabtagene autoleucel Regimen 2

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-2787 in adults with BRAF/NR...

Enrolling
Melanoma
Solid Tumor, Adult
Drug: KIN-2787 and binimetinib
Drug: KIN-2787

A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.

Enrolling
Fuchs Endothelial Corneal Dystrophy
Drug: Ripasudil
Drug: Placebo

A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.

Active, not recruiting
Fuchs Endothelial Corneal Dystrophy
Drug: Placebo
Drug: Ripasudil

The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migrain...

Enrolling
Migraine
Drug: Eptinezumab

The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among par...

Enrolling
Myocarditis Acute
Cancer
Drug: Abatacept plus
Drug: Placebo

The primary purpose of this study is to determine whether treatment with lecanemab is superior to placebo on change from baseline of the Preclinical...

Enrolling
Preclinical Alzheimer's Disease
Early Preclinical Alzheimer's Disease
Drug: Lecanemab
Drug: Placebo

A Phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 vs Physician's Choice Standard of Care for the Treatment of Locoregional,...

Enrolling
Head and Neck Cancer
Combination Product: ASP-1929 Photoimmunotherapy
Drug: Physician's Choice SOC

The objective of this study is to demonstrate the safety and efficacy of the Indigo Aspiration system for percutaneous mechanical thrombectomy in a p...

Enrolling
Deep Vein Thrombosis
DVT
Device: Indigo Aspiration System

The purpose of this study is to gather safety and effectiveness data on Stryker Neurovascular's Next Generation Target Detachable Coil (hereafter ref...

Enrolling
Unruptured Wide-neck Aneurysms
Device: Citadel Embolization Device

The C4 program aims to provide a multi-level intervention program (Patient Level, Healthcare Team and Healthcare System Level) that improves the coor...

Enrolling
Cancer
Health Care Utilization
Other: C4 Program

The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for...

Enrolling
Amyotrophic Lateral Sclerosis
Drug: Placebo
Drug: Masitinib (4.5)

The primary aims of this study is to determine the efficacy and tolerability of Extracorporeal Photopheresis (ECP) for the treatment of either Refrac...

Active, not recruiting
Bronchiolitis Obliterans Syndrome (BOS)
Other: No intervention in the SOC / Retrospective Chart review.
Combination Product: Extracorporeal Photopheresis (ECP)

A prospective, retrospective, non-randomized, multicenter study with two independent hernia study cohorts (Ventral / Incisional Hernia Repair and Dia...

Enrolling
Incisional Hernia
Hernia, Hiatal
Device: Gore ENFORM Biomaterial (Intraperitoneal)
Device: Gore ENFORM Biomaterial (Preperitoneal)

STACI is a prospective, multicenter, study of SIJ fusion using the iFuse TORQ implant system.

Active, not recruiting
Sacroiliac Disorder
Sacroiliac; Fusion
Device: Use of iFuse TORQ

Trial sponsors

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