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University of Massachusetts Chan Medical School | Medicine Department - Rheumatology Division

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Pembrolizumab
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NS-018
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Active trials

20 of 46 total trials

A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo

A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents with Nonsegmental Vitiligo (Active and Stable) Tranquillo

Enrolling
Stable Nonsegmental Vitiligo
Active Nonsegmental Vitiligo
Drug: Ritlecitinib
Drug: Placebo

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse....

Active, not recruiting
Cytochrome P-450
Antineoplastic Agents, Hormonal
Drug: Placebo for Abemaciclib
Drug: Abemaciclib

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine...

Enrolling
Endometrial Adenocarcinoma
Urothelial Carcinoma
Diagnostic Test: OncoSignature
Drug: ACR-368

The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refra...

Enrolling
Systemic Sclerosis
Idiopathic Inflammatory Myopathy
Drug: Fludarabine
Drug: CC-97540

This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a re...

Enrolling
X-ALD
AMN Gene Mutation
Genetic: SBT101
Procedure: Imitation Procedure

The purpose of this study is to evaluate the effect of moderate or severe liver impairment on the drug levels of oral azacitidine and the safety and...

Enrolling
Neoplasms
Hepatic Insufficiency
Drug: Onureg

The purpose of this study is to evaluate the effectiveness and safety of deucravacitinib compared with placebo in an active moderate to severe System...

Enrolling
Systemic Lupus Erythematosus
Drug: Deucravacitinib
Other: Placebo

The primary objective of this study is to evaluate the long-term safety and tolerability of litifilimab in participants with active systemic lupus er...

Invitation-only
Systemic Lupus Erythematosus (SLE)
Drug: Litifilimab-matching placebo
Drug: Litifilimab

The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide.There are 2 parts to this study...

Enrolling
Multiple Myeloma
Drug: Iberdomide
Drug: Elranatamab

This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called cemipli...

Enrolling
Melanoma
Drug: pembrolizumab
Drug: cemiplimab

The main purpose of this clinical study is to evaluate a 6-valent OspA-based Lyme disease vaccine (VLA15) for prevention of Lyme disease within North...

Active, not recruiting
Lyme Disease
Biological: VLA15
Other: Saline

The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and e...

Enrolling
COVID-19
Drug: nirmatrelvir
Drug: ritonavir

The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than swi...

Enrolling
Psoriatic Arthritis
Drug: Guselkumab
Drug: Golimumab
Recently updated

Researchers are looking for new ways to treat people with head and neck cancer whose cancer has come back after treatment (recurrent) or whose cancer...

Active, not recruiting
Squamous Cell Carcinoma of Head and Neck
Drug: Cetuximab
Drug: Capecitabine

To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patient...

Active, not recruiting
Glioblastoma Multiforme
Device: Optune®

This study will examine the safety and efficacy of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergenc...

Begins enrollment this month
Acute Stress Disorder
Neurocognitive Function
Drug: Placebo
Drug: Cyclobenzaprine HCl

A Phase 2/3 study to investigate the efficacy and safety of luveltamab tazevibulin versus IC chemotherapy in women with ovarian cancer (including fal...

Enrolling
Primary Peritoneal Cancer
Epithelial Ovarian Cancer
Drug: Luveltamab tazevibulin
Drug: Gemcitabine

AOC 1044-CS1 (EXPLORE44) is a Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of single and multi...

Active, not recruiting
Exon 44
Duchenne Muscular Dystrophy
Drug: Placebo
Drug: AOC 1044

Researchers are looking for new ways to treat people with locally advanced non-small cell lung cancer (NSCLC). The goal of this study is to learn if...

Enrolling
Carcinoma, Non-Small-Cell Lung
Drug: carboplatin
Drug: etoposide

Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a...

Enrolling
Lower Respiratory Tract Illness
Biological: RSVpreF
Biological: Placebo

Trial sponsors

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University of North Carolina (UNC) logo
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