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University of Miami | Bascom Palmer Eye Institute

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Ranibizumab
APL-2
Pegcetacoplan
Linsitinib
Bevacizumab
LX201
GT005
Ripasudil
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Active trials

11 of 84 total trials

A Phase 2b Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

The overall study objective is to continue to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of linsitinib in subjects who were...

Enrolling
Thyroid Diseases
Graves Ophthalmopathy
Drug: linsitinib

The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twi...

Active, not recruiting
Thyroid Diseases
Graves Ophthalmopathy
Drug: Placebo
Drug: Linsitinib

This Phase 2 study is a non-randomized, open-label, study of the safety of AGTC-501 in participants with XLRP who have previously been treated with a...

Invitation-only
X-Linked Retinitis Pigmentosa
Biological: AGTC-501 (high dose and standard corticosteroid regimen)
Biological: AGTC-501 (low dose and standard corticosteroid regimen)

A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.

Enrolling
Fuchs Endothelial Corneal Dystrophy
Drug: Placebo
Drug: Ripasudil

A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.

Enrolling
Fuchs Endothelial Corneal Dystrophy
Drug: Placebo
Drug: Ripasudil

This is a phase 3, open-label, multicenter, extension study to evaluate the long-term safety and efficacy of pegcetacoplan (APL-2) in subjects with g...

Active, not recruiting
Geographic Atrophy Secondary to Age-related Macular Degeneration
Drug: PEGCETACOPLAN (APL-2)

This study will evaluate the safety and tolerability of ATSN-201 in male subjects ≥ 6 years of age with RS1-associated X-linked retinoschisis (XLRS).

Enrolling
X-linked Retinoschisis
Biological: ATSN-201

In this early feasibility trial the safety and performance of the new retinal prothesis PRIMA is tested in five subjects suffering from atrophic dry...

Active, not recruiting
Dry Age-related Macular Degeneration
Device: PRIMA

The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of EDIT-101 administered via subretinal i...

Active, not recruiting
Eye Diseases, Hereditary
Inherited Retinal Dystrophies
Drug: EDIT-101

This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410ST for Stargardt Disease.This is a multicenter study, which will be conducted in...

Enrolling
Stargardt Disease
Genetic: OCU410ST

This is a double-masked, randomized, parallel-assignment, multicenter trial examining the safety and tolerability of teprotumumab in the treatment of...

Active, not recruiting
Thyroid Eye Disease
Drug: Teprotumumab
Drug: Placebo

Trial sponsors

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