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University of Miami | Bascom Palmer Eye Institute

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Ranibizumab
APL-2
LX201
Linsitinib
GT005
Pegcetacoplan
Ripasudil
Bevacizumab
AU-011
Lidocaine

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Active trials

15 of 88 total trials

A Phase 2b Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

The overall study objective is to continue to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of linsitinib in subjects who were...

Enrolling
Thyroid Diseases
Graves Ophthalmopathy
Drug: linsitinib

The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twi...

Active, not recruiting
Thyroid Diseases
Graves Ophthalmopathy
Drug: Placebo
Drug: Linsitinib
Locations recently updated

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary i...

Enrolling
Indeterminate Lesions
Ocular Melanoma
Device: Suprachoroidal Microinjector
Drug: Bel-sar

This Phase 2 study is a non-randomized, open-label, study of the safety of AGTC-501 in participants with XLRP who have previously been treated with a...

Invitation-only
X-Linked Retinitis Pigmentosa
Biological: AGTC-501 (high dose and modified corticosteroid regimen)
Biological: AGTC-501 (high dose and standard corticosteroid regimen)

A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.

Enrolling
Fuchs Endothelial Corneal Dystrophy
Drug: Ripasudil
Drug: Placebo
Locations recently updated

Phase 2b trial of TOUR006 in Thyroid Eye Disease (TED) to evaluate 20mg and 50mg doses against placebo given by a subcutaneous injection every eight...

Enrolling
Thyroid Eye Disease
Other: Placebo
Drug: TOUR006 - 50 MG

A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.

Enrolling
Fuchs Endothelial Corneal Dystrophy
Drug: Placebo
Drug: Ripasudil

This is a phase 3, open-label, multicenter, extension study to evaluate the long-term safety and efficacy of pegcetacoplan (APL-2) in subjects with g...

Active, not recruiting
Geographic Atrophy Secondary to Age-related Macular Degeneration
Drug: PEGCETACOPLAN (APL-2)

This study will evaluate the safety and tolerability of ATSN-201 in male subjects ≥ 6 years of age with RS1-associated X-linked retinoschisis (XLRS).

Enrolling
X-linked Retinoschisis
Biological: ATSN-201
New

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with choroidal metastasis from breast or lung primary...

Begins enrollment this month
Eye Cancer
Lung Cancer
Drug: AU-011
Device: SCS Microinjector

In this early feasibility trial the safety and performance of the new retinal prothesis PRIMA is tested in five subjects suffering from atrophic dry...

Active, not recruiting
Dry Age-related Macular Degeneration
Device: PRIMA

The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of EDIT-101 administered via subretinal i...

Active, not recruiting
Eye Diseases, Hereditary
Inherited Retinal Dystrophies
Drug: EDIT-101

This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410ST for Stargardt Disease.This is a multicenter study, which will be conducted in...

Enrolling
Stargardt Disease
Genetic: OCU410ST
Locations recently updated

This study is an open-label, single ascending dose clinical trial in participants who have ABCA4-related retinopathies. This is the first-in-human cl...

Enrolling
Cone Rod Dystrophy
Stargardt Disease
Drug: ACDN-01

This is a double-masked, randomized, parallel-assignment, multicenter trial examining the safety and tolerability of teprotumumab in the treatment of...

Active, not recruiting
Thyroid Eye Disease
Drug: Teprotumumab
Drug: Placebo

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