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Active trials

27 of 236 total trials

24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG

This is a Phase 2, randomized, open-label, 24-week treatment study to evaluate the potential pharmacodynamic (PD) activity, safety, tolerability, and...

Enrolling
Pmm2-CDG
Drug: GLM101

This trial is an extension of the antecedent trial ARGX-117-2002. It is a multicenter trial that has been designed to evaluate the long-term safety a...

Invitation-only
Multifocal Motor Neuropathy (MMN)
Other: Placebo
Biological: ARGX-117

This study will compare the efficacy and safety of HLX04-O administered by intravitreal injection (IVT) with ranibizumab in patients with active wAMD.

Active, not recruiting
Age Related Macular Degeneration
Drug: HLX04-O
Drug: ranibizumab

This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight i...

Enrolling
Obesity
Drug: Semaglutide
Drug: Placebo

This is a global, multicenter, open-label safety extension study. Participants receiving single-agent trastuzumab emtansine or trastuzumab emtansine...

Active, not recruiting
Neoplasm Metastasis
Drug: Trastuzumab
Drug: Pertuzumab

This study will be conducted in 2 parts. The first part is a phase 1 single-agent dose escalation,optimization, and expansion study of tegavivint in...

Enrolling
Advanced Hepatocellular Carcinoma
Drug: Pembrolizumab
Drug: Tegavivint

A Phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 vs Physician's Choice Standard of Care for the Treatment of Locoregional,...

Enrolling
Head and Neck Cancer
Combination Product: ASP-1929 Photoimmunotherapy
Drug: Physician's Choice SOC

This is a prospective, multi-center, randomized, controlled, patient- and evaluator-blinded study comparing treatment with the CardiAMP cell therapy...

Active, not recruiting
Heart Failure, Systolic
Other: Sham
Biological: Autologous cell therapy

Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Rest...

Enrolling
Dilated Cardiomyopathy
Heart Failure With Reduced Ejection Fraction (HFrEF)
Device: AccuCinch Ventricular Restoration System
Drug: Guideline-Directed Medical Therapy

The study will evaluate if Leuprolide Mesylate is safe and effective in the treatment of subjects with central (gonadotropin-dependent) precocious pu...

Enrolling
Puberty; Precocious, Central
Drug: Leuprolide Mesylate, Subcutaneous injection of 42 mg Leuprolide

PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointe...

Enrolling
Gastrointestinal Complication
Device: PrevisEA device

First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion...

Active, not recruiting
Non Small Cell Lung Cancer Metastatic
Platinum Resistant Ovarian Cancer
Drug: upifitamab rilsodotin

The objective of this study is to assess the therapeutic efficacy of a hematopoietic cell-based gene therapy for patients with Fanconi anemia, subtyp...

Active, not recruiting
Fanconi Anemia Complementation Group A
Biological: RP-L102

The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surger...

Enrolling
Recurrent Brain Metastases
Procedure: Craniotomy
Radiation: Cesium-131 brachytherapy

Prospective, multi-center, single-arm, seamless phase-pivotal study conducted in participants diagnosed with UUI who have failed or could not tolerat...

Active, not recruiting
Urinary Urgency Incontinence
Device: Neuspera Implantable Sacral Nerve Stimulation System

A Randomized, Double-blind, Placebo-controlled, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Explora...

Enrolling
Muscular Dystrophy, Landouzy Dejerine
Fascioscapulohumeral Muscular Dystrophy
Drug: AOC 1020
Drug: Placebo

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...

Enrolling
Metastatic Cancer
Advanced Cancer
Drug: Cetuximab
Drug: Afatinib

Liposorber® LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circu...

Enrolling
Focal Segmental Glomerulosclerosis
Device: LIPOSORBER® LA-15 System

This trial will be a randomized controlled study comparing the efficacy and safety of intraoperative radiation therapy using GammaTilesTM (GT) versus...

Enrolling
Brain Metastases
Radiation: Stereotactic Radiation Therapy
Device: Gamma Tile-Surgically Targeted Radiation Therapy (STaRT)
Recently updated

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Enrolling
Lupus Nephritis
Systemic Lupus Erythematosus
Biological: CABA-201

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