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University of Minnesota | Pediatric Endocrinology Department

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Active trials

32 of 288 total trials

A Clinical Trial to Investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults With Multifocal Motor Neuropathy (ARDA+)

This trial is an extension of the antecedent trial ARGX-117-2002. It is a multicenter trial that has been designed to evaluate the long-term safety a...

Active, not recruiting
Multifocal Motor Neuropathy (MMN)
Biological: ARGX-117
Other: Placebo

This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight i...

Active, not recruiting
Obesity
Drug: Semaglutide
Drug: Placebo

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche...

Active, not recruiting
Multiple Sclerosis
Drug: Ocrelizumab

This is a global, multicenter, open-label safety extension study. Participants receiving single-agent trastuzumab emtansine or trastuzumab emtansine...

Active, not recruiting
Neoplasm Metastasis
Drug: Trastuzumab
Drug: Pertuzumab

The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of atumelnant treatment in pediatric...

Enrolling
Classic Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia
Drug: Atumelnant
Drug: Placebo

This study will be conducted in 2 parts. The first part is a phase 1 single-agent dose escalation,optimization, and expansion study of tegavivint in...

Enrolling
Advanced Hepatocellular Carcinoma
Drug: Lenvatinib
Drug: Tegavivint

The main purpose of this study is to look at the effect (efficacy) and safety of efgartigimod IV in participants with primary immune thrombocytopenia...

Enrolling
Primary Immune Thrombocytopenia (ITP)
Other: Placebo IV
Biological: Efgartigimod IV

The main purpose of this study is to compare empasiprubart and IVIg in adult patients with MMN. The study consists of a double-blinded part A (empasi...

Enrolling
MMN
Multifocal Motor Neuropathy (MMN)
Other: Empasiprubart-placebo
Biological: IVIG (Intravenous Immunoglobulin)

The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-a...

Enrolling
Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Drug: Avacopan
Drug: Standard of Care

This study is open to children aged 2 to 17 with chronic kidney disease (CKD). The purpose of this study is to find out if a medicine called empaglif...

Enrolling
Chronic Kidney Disease
Drug: Placebo
Drug: Empagliflozin

This is a Phase 1/2, open-label, multiple-center, dose escalation and cohort expansion study to evaluate the safety and efficacy of NGGT002 in adult...

Enrolling
Phenylketonurias
Genetic: NGGT002

A Phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 vs Physician's Choice Standard of Care for the Treatment of Locoregional,...

Active, not recruiting
Head and Neck Cancer
Combination Product: ASP-1929 Photoimmunotherapy
Drug: Physician's Choice SOC

Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Rest...

Enrolling
Dilated Cardiomyopathy
Heart Failure With Reduced Ejection Fraction (HFrEF)
Device: AccuCinch Ventricular Restoration System
Drug: Guideline-Directed Medical Therapy

This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple a...

Enrolling
Type 1 Diabetes Patients
Type 1 Diabetes Mellitus
Drug: CNP-103
Drug: Placebo

The study will evaluate if Leuprolide Mesylate is safe and effective in the treatment of subjects with central (gonadotropin-dependent) precocious pu...

Active, not recruiting
Puberty; Precocious, Central
Drug: Leuprolide Mesylate, Subcutaneous injection of 42 mg Leuprolide

PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointe...

Enrolling
Gastrointestinal Complication
Device: PrevisEA device

First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion...

Active, not recruiting
Non Small Cell Lung Cancer Metastatic
Platinum Resistant Ovarian Cancer
Drug: upifitamab rilsodotin

The objective of this study is to assess the therapeutic efficacy of a hematopoietic cell-based gene therapy for patients with Fanconi anemia, subtyp...

Active, not recruiting
Fanconi Anemia Complementation Group A
Biological: RP-L102

The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surger...

Enrolling
Recurrent Brain Metastases
Radiation: Cesium-131 brachytherapy
Procedure: Craniotomy

Prospective, multi-center, single-arm, seamless phase-pivotal study conducted in participants diagnosed with UUI who have failed or could not tolerat...

Active, not recruiting
Urinary Urgency Incontinence
Device: Neuspera Implantable Sacral Nerve Stimulation System

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