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University of North Carolina at Chapel Hill | Institute of Global Health and Infectious Disease

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Active trials

34 of 281 total trials

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus (AMETHYST)

In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE)....

Enrolling
Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus
Drug: Litifilimab
Drug: Placebo

This is a phase 2, randomized, double-blinded, placebo-controlled, parallel-group, multicenter trial to evaluate the safety and efficacy of 2 dose re...

Active, not recruiting
Multifocal Motor Neuropathy
Other: Placebo
Biological: ARGX-117

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lympho...

Active, not recruiting
Leukemia
Drug: Methotrexate
Drug: Thioguanine

A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal demen...

Active, not recruiting
Frontotemporal Dementia
Drug: Open label - AL001
Drug: AL001

This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plu...

Active, not recruiting
Diffuse Large B-Cell Lymphoma
Drug: Vincristine Placebo
Drug: Polatuzumab vedotin Placebo

The purpose of this study is to assess the efficacy and safety of tiragolumab, an anti-TIGIT monoclonal antibody, when administered in combination wi...

Enrolling
Carcinoma, Hepatocellular
Drug: Tiragolumab
Other: Placebo

The primary objective of this study is to compare belzutifan to everolimus with respect to progression-free survival (PFS) per Response Evaluation Cr...

Active, not recruiting
Carcinoma, Renal Cell
Drug: Everolimus
Drug: Belzutifan

The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with moderately to severely active ulcerative colitis...

Active, not recruiting
Ulcerative Colitis
Drug: Guselkumab
Drug: Placebo

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435. LOXO-435 may be used to treat cancer o...

Enrolling
Urinary Bladder Neoplasms
Neoplasm Metastasis
Drug: LOXO-435
Drug: Pembrolizumab

This study evaluates the safety of abemaciclib in combination therapies (letrozole, anastrozole, tamoxifen, exemestane, exemestane plus everolimus, t...

Active, not recruiting
Breast Neoplasms
Drug: Trastuzumab
Drug: Pertuzumab

The main aim is to see how the combination of pevonedistat + venetoclax + azacitidine compares to venetoclax + azacitidine in adults recently diagnos...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Drug: Pevonedistat
Drug: Venetoclax

TAK-981 is being tested in combination with pembrolizumab to treat participants who have select advanced or metastatic solid tumors.The study aims ar...

Active, not recruiting
Advanced or Metastatic Solid Tumors
Drug: Pembrolizumab
Drug: TAK-981

This is a biomarker preselected, randomized, open-label, multicenter, phase II study in men with metastatic castration resistant prostate cancer (mCR...

Active, not recruiting
Abnormal DNA Repair
Prostate Cancer Metastatic Castration-Resistant
Drug: Abiraterone Acetate
Drug: Prednisone

The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/s...

Enrolling
Nasal Congestion and Inflammations
Sinus Congestion Chronic
Other: SinuSonic

This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 y...

Enrolling
Diabetic Retinopathy
Other: Placebo
Drug: Fenofibrate

The purpose of this study is to characterize the safety, tolerability, PK, and efficacy of INCB 99280 in combination with ipilimumab in participants...

Active, not recruiting
Melanoma
Renal Cell Carcinoma (RCC)
Drug: INCB 99280 with Ipilimumab

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizum...

Enrolling
Solid Tumors
Hematologic Malignancies
Drug: Pembrolizumab
Drug: Lenvatinib

This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy/performance and safe...

Enrolling
Aged
Locally Advanced Head and Neck Squamous Cell Carcinoma
Radiation: Radiation Therapy
Drug: NBTXR3

The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with I...

Enrolling
Invasive Aspergillosis
Drug: Olorofim
Drug: AmBisome®

The Phoenix Trial is a randomized double blind placebo controlled Phase III trial to evaluate the safety and efficacy of AMX0035 for treatment of ALS

Active, not recruiting
Amyotrophic Lateral Sclerosis
Other: Placebo
Drug: AMX0035

Trial sponsors

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