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Upadacitinib
Ixekizumab
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JNJ-88545223

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Angela R. Crowley, MD, FACR

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Active trials

28 of 29 total trials

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffn...

Enrolling
Radiographic Axial Spondyloarthritis
Drug: Placebo
Drug: Tulisokibart

The primary objective of this trial is to evaluate the effect of pegloticase 18 mg subcutaneously (SC) every two weeks with methotrexate (MTX) versus...

Enrolling
Uncontrolled Gout
Drug: Pegloticase
Drug: Methotrexate

This is a prospective, open-label, single arm 3-year clinical study to describe the short-term and long-term efficacy and safety of belimumab in part...

Enrolling
Systemic Lupus Erythematosus
Drug: Belimumab (GSK1550188)

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by...

Enrolling
Arthritis, Psoriatic
Drug: Placebo
Drug: Guselkumab

The main purpose of this study is to evaluate the effects of LY3541860 in adult participants with moderately to severely active Rheumatoid Arthritis...

Active, not recruiting
Rheumatoid Arthritis
Drug: LY3541860

This study aims to examine the efficacy and safety of obexelimab in participants with systemic lupus erythematosus (SLE).

Enrolling
Systemic Lupus Erythematosus
Drug: Placebo
Drug: Obexelimab

The main purpose of the proposed study is to evaluate the efficacy of efgartigimod PH20 SC in patients with moderate-to-severe Primary Sjögren's Dise...

Enrolling
Primary Sjogrens Disease
Biological: Efgartigimod PH20 SC
Other: Placebo PH20 SC

This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe...

Enrolling
Rheumatoid Arthritis
Drug: Placebo
Drug: Afimkibart

Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate th...

Enrolling
Rheumatoid Arthritis
Drug: Lutikizumab
Drug: Placebo

The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achi...

Enrolling
Systemic Lupus Erythematosus
Drug: DZP
Other: Placebo

The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in participants with active psoriatic arthritis (PsA) by ass...

Enrolling
Arthritis, Psoriatic
Drug: Placebo
Drug: Active reference comparator

The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with ac...

Enrolling
Arthritis, Psoriatic
Drug: JNJ-88545223
Drug: Placebo

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participan...

Enrolling
Overweight or Obesity
Psoriatic Arthritis
Drug: Tirzepatide

Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163.

Enrolling
Rheumatoid Arthritis
Drug: AZD1163
Other: Placebo

The purpose of this multicenter, randomized, placebo-controlled and double-blind study is to evaluate the efficacy and safety of subcutaneous anifrol...

Enrolling
Polymyositis, Dermatomyositis
Combination Product: Anifrolumab (unblinded, open label)
Combination Product: Anifrolumab (blinded)

The study consists of 24-week double-blind trial to evaluate the non-inferiority of the efficacy and safety of pegloticase Q4W with MTX versus peglot...

Active, not recruiting
Gout
Drug: Methotrexate
Biological: Pegloticase

A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SS...

Enrolling
Myositis
Refractory Rheumatoid Arthritis (RA)
Drug: Allogeneic NK Cells

The main purpose of this study is to evaluate the efficacy and safety of LY3871801 in adult participants with active moderately-to-severe rheumatoid...

Enrolling
Rheumatoid Arthritis
Drug: LY3871801
Drug: Placebo

The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at leas...

Active, not recruiting
Obesity
Psoriatic Arthritis
Drug: Tirzepatide
Drug: Ixekizumab

The purpose of this study is to evaluate the clinical efficacy and safety of nipocalimab in participants with moderate to severe Sjogren's disease (S...

Enrolling
Sjogrens Syndrome
Drug: Placebo
Drug: Standard of care treatment

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