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Active trials

9 of 79 total trials

A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for...

Enrolling
Uterine Fibroids
Endometriosis
Drug: Relugolix Combination Tablet

A Study Comparing the Safety, Tolerability, and Pharmacokinetics of Sabirnetug IV and Sabirnetug + rHuPH20 SC in Healthy Participants

Enrolling
Alzheimer Disease
Drug: sabirnetug (ACU193)
Combination Product: Sabirnetug + rHuPH20

The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with hypothalami...

Enrolling
Hypothalamic Obesity
Drug: Part B: RM-718 or placebo (matched to specific RM-718 dose cohort)
Drug: Part A: RM-718 or placebo (matched to specific RM-718 dose cohort)

The purpose of this study to assess the relative bioavailability of 5 mg Mavacamten opened capsule administered via nasogastric tube compared to inta...

Enrolling
Healthy Volunteers
Drug: Treatment C: Mavacamten open capsule in suspension administered via nasogastric tube (NGT)
Drug: Treatment A: Mavacamten intact oral capsule

A randomized, double-blind, placebo-controlled, dose-escalation study will be conducted in healthy volunteers. This study will evaluate the safety, t...

Enrolling
Gout
Drug: ABP-745
Drug: Placebo

The primary objectives of this study are to assess the safety, tolerability, and efficacy of ABP-671 in lowering serum uric acid (sUA) in participant...

Invitation-only
Gout
Drug: Allopurinol
Drug: ABP-671

To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions.To evaluat...

Enrolling
Hypertonia, Muscle
Spinal Cord Injuries
Drug: MTR-601

AOC 1044-CS1 (EXPLORE44) is a Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of single and multi...

Enrolling
Exon 44
Duchenne Muscular Dystrophy
Drug: Placebo
Drug: AOC 1044

The purpose of this study is to assess the contraceptive efficacy of relugolix combination therapy.

Active, not recruiting
Contraception
Drug: Relugolix Combination Therapy

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