0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy

Mahidol University

Status and phase: Unknown; Phase 4

Conditions: Pain

Treatments: Drug: Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01080911

Si073/2010

Details and patient eligibility

About

This study aims to compare the effect of spinal morphine between the dose 0.05 mg and 0.1 mg on the amount of morphine during the first 24 hours postoperative.

Enrollment: 72 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female ASA 1-3
• Undergoing vaginal hysterectomy with/without anterior and posterior vaginoplasty
• Can operate PCA device

Exclusion criteria

• History of allergy to the study drugs
• History of bleeding tendency
• History of infection at the back
• Patient refuse to have spinal anesthesia
• History of CAD or CVD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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72 participants in 2 patient groups

spinal morphine 0.05 mg

Experimental group

Description:

spinal morphine 0.05 mg plus 0.5% heavy marcaine 3.5 ml

Treatment:

Drug: Morphine

Drug: Morphine

spinal morphine 0.1 mg

Active Comparator group

Description:

spinal morphine 0.1 mg plus 0.5% heavy marcaine 3.5 ml

Treatment:

Drug: Morphine

Drug: Morphine