0.05 Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy

Mahidol University

Status and phase: Unknown; Phase 4

Conditions: Vaginal Hysterectomy; Pain

Treatments: Drug: Spinal morphine 0.1 mg; Drug: Spinal morphine 0.05 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT01079754

Si 073/2010

Details and patient eligibility

About

This study aims to compare the efficacy of 0.05 mg and 0.1 mg spinal morphine in reducing postoperative morphine requirement in patients undergoing vaginal hysterectomy with/without anterior and posterior vaginoplasty.

Enrollment: 72 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female ASA physical status 1-3
• Undergoing vaginal hysterectomy with/without anterior and posterior vaginoplasty
• Be able to operate patient-controlled analgesia (PCA)

Exclusion criteria

• Allergy to the study drugs
• History of bleeding tendency
• Infection at the back
• Refuse to spinal anesthesia
• History of CAD or CVA

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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72 participants in 2 patient groups

Spinal morphine 0.05 mg

Experimental group

Description:

Patient received spinal morphine 0.05 mg

Treatment:

Drug: Spinal morphine 0.05 mg

Spinal morphine 0.1 mg

Active Comparator group

Description:

Patient received spinal morphine 0.1 mg

Treatment:

Drug: Spinal morphine 0.1 mg