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0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia

N

National Cheng-Kung University

Status

Completed

Conditions

Hospital-acquired Pneumonia

Treatments

Other: Normal Saline Product
Drug: Listerine Oral Liquid Product
Drug: 0.12% Chlorhexidine Oral Liquid Product

Study type

Interventional

Funder types

Other

Identifiers

NCT04403971
A-ER-108-309

Details and patient eligibility

About

Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.

Full description

Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.

Enrollment

103 patients

Sex

All

Ages

20 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Hospitalized patients > 20 years old without ventilator

Exclusion criteria

  • known hypersensitivity to or intolerance of Chlorhexidine or Listerine

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Sequential Assignment

Masking

Triple Blind

103 participants in 3 patient groups, including a placebo group

0.12% chlorhexidine
Experimental group
Description:
Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers.
Treatment:
Drug: 0.12% Chlorhexidine Oral Liquid Product
Listerine
Sham Comparator group
Description:
Participants will be randomized to Listerine solution group, applied twice a day by care givers.
Treatment:
Drug: Listerine Oral Liquid Product
Normal saline
Placebo Comparator group
Description:
Participants will be randomized to Normal saline group, applied twice a day by care givers.
Treatment:
Other: Normal Saline Product

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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