0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia

National Cheng-Kung University

Status: Completed

Conditions: Hospital-acquired Pneumonia

Treatments: Other: Normal Saline Product; Drug: Listerine Oral Liquid Product; Drug: 0.12% Chlorhexidine Oral Liquid Product

Study type: Interventional

Funder types: Other

Identifiers

NCT04403971

A-ER-108-309

Details and patient eligibility

About

Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.

Full description

Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.

Enrollment: 103 patients

Sex: All

Ages: 20 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized patients > 20 years old without ventilator

Exclusion criteria

• known hypersensitivity to or intolerance of Chlorhexidine or Listerine

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Triple Blind

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103 participants in 3 patient groups, including a placebo group

0.12% chlorhexidine

Experimental group

Description:

Participants will be randomized to Chlorhexidine solution group, applied twice a day by care givers.

Treatment:

Drug: 0.12% Chlorhexidine Oral Liquid Product

Listerine

Sham Comparator group

Description:

Participants will be randomized to Listerine solution group, applied twice a day by care givers.

Treatment:

Drug: Listerine Oral Liquid Product

Normal saline

Placebo Comparator group

Description:

Participants will be randomized to Normal saline group, applied twice a day by care givers.

Treatment:

Other: Normal Saline Product