1-1-12 Wash-in for Desflurane Low Flow Anesthesia

Khon Kaen University

Status: Completed

Conditions: Anesthesia

Treatments: Procedure: 1-1-12 wash-in

Study type: Observational

Funder types: Other

Identifiers

NCT02013882

HE561247

Details and patient eligibility

About

We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.

Full description

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Enrollment: 106 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA classification I-II
• age 18-64 years

Exclusion criteria

• BMI > 35
• contraindicated for N2O
• with pulmonary or cardiac disease

Trial design

106 participants in 1 patient group

1-1-12 wash-in

Description:

wash-in using O2:N2O 1:1 L/min with desflurane 12%

Treatment:

Procedure: 1-1-12 wash-in