1% Lidocaine Paracervical Block for Endometrial Biopsy

Mount Sinai Hospital, Canada

Status

Enrolling

Conditions

Endometrial Biopsy

Treatments

Other: Capped needle

Drug: Lidocaine 1% Injectable Solution

Study type

Interventional

Funder types

Other

Identifiers

NCT06546254

REB 23-0078-A

Details and patient eligibility

About

The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention.

The proposed study is a double-blind randomized controlled trial (RCT).

Each participant will be randomly assigned to one of two arms:

intervention (paracervical block - 10 mL 1% lidocaine with epinephrine)
control (gently tapping the cervicovaginal junction with a capped needle)

The primary outcome will be a global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) following the procedure.

Enrollment

96 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Any participant > or = age 18 years old presenting for an endometrial biopsy
All parities of patients are eligible
English speaking participants only

Exclusion Criteria

Use of pain medication that is not an NSAID or acetaminophen (e.g. opioids, benzos) within past 24 hours
Confirmed pregnancy
Any diagnosed chronic pain syndromes (eg. fibromyalgia, vaginismus, interstitial cystitis)
Contraindication to lidocaine
Misoprostol administration within 24 hours
Previous unsuccessful office attempt at endometrial biopsy by the same practitioner (note of clarification: previous unsuccessful biopsy attempt by a different practitioner will still be eligible)