10-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals (ADARFEP_10Y)

Fundación Marques de Valdecilla

Status

Unknown

Conditions

Schizophrenia Spectrum and Other Psychotic Disorders

Schizophrenia

Schizophrenia Relapse

Treatments

Other: Maintenance treatment discontinuation

Other: Antipsychotic treatment discontinuation

Study type

Interventional

Funder types

Other

NETWORK

Identifiers

NCT03090490

ADARFEP_10Y

Details and patient eligibility

About

This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the ten years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with schizophrenia spectrum disorder.

Enrollment

68 estimated patients

Sex

All

Ages

15 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Individuals included in the First Episode Psychosis Clinical Program (PAFIP) at the University Hospital Marqués de Valdecilla (Santander, Spain).
A minimum of 18 months on antipsychotic treatment.
Meeting clinical remission criteria for at least the 12 months prior to inclusion.
Meeting the functional recovery criteria for at least the 6 months prior to inclusion.
Stabilized at the lowest effective doses for at least the 3 months prior to inclusion.

Exclusion criteria

Meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for drug dependence.
Meeting DSM-IV criteria for mental retardation.
Having a history of neurological disease or head injury.