12-Month Stability of Diurnal IOP Control on Cosopt

West Virginia University

Status and phase: Completed; Phase 4

Conditions: Glaucoma

Treatments: Drug: Cosopt

Study type: Interventional

Funder types: Other

Identifiers

NCT00379834

31861

Details and patient eligibility

About

To determine the stability of diurnal intraocular pressure in eyes with glaucoma treated with Cosopt

Full description

Glaucoma is a potentially-blinding but treatable eye disease. A major risk factor for glaucoma is elevated intraocular pressure (IOP). IOP is a dynamic variable (like blood pressure)-it changes over time. The more it changes, the more likely patients are to get worse. Glaucoma is treated by lowering IOP. Cosopt is a medication that lowers IOP. Little is known about how well Cosopt reduces IOP fluctuations. In this study, we plan to measure the IOP in both eyes of 10 glaucoma patients treated with Cosopt, every 2 hours from 8am to 8pm, on five separate days over a one-year period. Untreated baseline IOP will be measured on a similar long day before beginning treatment with Cosopt. This methodology will allow us to compare IOP fluctuations with and without Cosopt, and also to learn about long-term control of IOP fluctuations in eyes treated with Cosopt.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bilateral open-angle glaucoma

Exclusion criteria

• contraindications to Cosopt
• pathology affecting tonometry

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Cosopt

Active Comparator group

Description:

Cosopt twice daily in both eyes

Treatment:

Drug: Cosopt