12 Weeks of Hemodialysis With Medium Cut-Off Filter Compared to Hemodiafiltration With Standard High-flux Filter.

Region Skane

Status: Withdrawn

Conditions: Chronic Kidney Diseases; Uremia

Treatments: Device: MCO-HD; Device: high-flux HDF

Study type: Interventional

Funder types: Other

Identifiers

NCT03416192

2017/830/2

Details and patient eligibility

About

The medium cut-off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.

The aim of this study is to compare levels of middle molecules after 12 weeks of MCO hemodialysis, compared to 12 weeks of hemodiafiltration using standard high-flux filter.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ongoing HDF treatment (>3 months)
• Oliguric
• Albumin ≥ 30
• CRP <15
• No acute myocardial infarction within 3 months.
• Swedish or english speaking.

Exclusion criteria

• Not able to understand the study information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

MCO-HD

Experimental group

Description:

Hemodialysis with Medium Cut-Off filter

Treatment:

Device: high-flux HDF

Device: MCO-HD

High-flux HDF

Active Comparator group

Description:

Hemodiafiltration with standard high-flux filter

Treatment:

Device: high-flux HDF

Device: MCO-HD