14-3-3η Protein, Disease Activity and Bone Mineral Density, in Female Patients With Rheumatoid Arthritis

Al-Azhar University

Status: Completed

Conditions: Osteoporosis; Rheumatoid Arthritis

Treatments: Diagnostic Test: 14-3-3η Protein assay

Study type: Observational

Funder types: Other

Identifiers

NCT03999528

Rheu-med.9med.research

Details and patient eligibility

About

Is to investigate the relation between 14-3-3η protein, disease activity, and bone mineral density in female patients with rheumatoid arthritis.

Full description

Methods: all patients in the study will subject to:

• Clinical assessment, WT, Height ,BMI, parity, medications,
• DAS 28.
• Serum 14-3-3η protein.
• DEXA scan.

Grouping:

• Group I: RA Patients with low BMD.
• Group II: RA Patients with normal BMD.
• Group III: normal control.

Enrollment: 45 patients

Sex: Female

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Rheumatoid arthritis according to ACR 2010 criteria with at least one year duration.
• Premenopausal females.
• On conventional DMARD with maximum 5 mg steroids.

Exclusion criteria

• Biological treatment.
• Previous antiresorptive treatment, or bone anabolics.
• High dose corticosteroid.
• Chronic renal or kidney disease.
• Medications affecting bone metabolism.
• Thyroid or adrenal dysfunction,

Trial design

45 participants in 2 patient groups

study group

Description:

RA Patients

Treatment:

Diagnostic Test: 14-3-3η Protein assay

control group

Description:

normal control

Treatment:

Diagnostic Test: 14-3-3η Protein assay